Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
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Manner in mdx Mice
Limin Cao1,2, Gang Han1, Caorui Lin1, Ben Gu1, Xianjun Gao1, Hong M Moulton3, Yiqi
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Poetry in the People's Republic of China during the past 30 years has been dominated by works intensely political in nature – a kind of poetry known by the name zhengzhi shuqing shi (political lyric). The function of this poetry was to eulogize current political movements and to generate public...
Cross sections for radiative neutron capture have been determined for ⁹⁴Zr and ⁹⁶Zr using the activation technique with samples of naturally occurring Zr metal. The sensitivity to the correction for epithermal neutrons in the determination of small thermal cross sections is discussed, particularly in view of the variation in the...
Aggressive random testing tools (“fuzzers”) are impressively effective
at finding compiler bugs. For example, a single test-case
generator has resulted in more than 1,700 bugs reported for a single
JavaScript engine. However, fuzzers can be frustrating to use:
they indiscriminately and repeatedly find bugs that may not be severe
enough...