We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as
B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity
of morpholino phosphorodiamidate oligomers (PMOs) in dystrophin-deficient mdx mice. In the present study, the general
mechanistic significance of the...
Full Text:
Boutilier5, Qingsong Wang1, Anthony
Walsh2, Bernard Lebleu3 and Matthew JA Wood2
Molecular Therapy
We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as
B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity
of morpholino phosphorodiamidate oligomers (PMOs) in dystrophin-deficient mdx mice. In the present study, the general
mechanistic significance of the...
We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as
B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity
of morpholino phosphorodiamidate oligomers (PMOs) in dystrophin-deficient mdx mice. In the present study, the general
mechanistic significance of the...
Morpholino oligos (Morpholinos) are widely used tools for knocking down gene expression and are currently in a clinical trial for treatment of Duchene muscular dystrophy. A Morpholino analog has been in a clinical trial as a potential anti-bioterrorism agent for inhibiting replication of deadly Marburg viral infection. The cellular uptake...
Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand
RNA viruses which infect the respiratory mucosa of animals and humans. Despite
decades of research and development of antivirals and vaccines, both of these viruses
continue to be a major health concern throughout the world. The focus of...
Many humans and canines alike suffer from osteosarcoma, which is often metastatic, resistant to chemotherapy, and frequently fatal. The mechanisms through which osteosarcoma cells acquire resistance to chemotherapy are not entirely understood, and the role of exosomes as intercellular mediators of this resistance in osteosarcoma is unknown. Using established canine...