Childhood tooth decay is a prevalent and concerning public health issue that is often misunderstood or dismissed. In Oregon specifically, over 50% of children have experienced at least one instance of tooth decay and these rates are even higher for marginalized communities such as children living in poverty, children of...
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PhilipMcFadden
Childhood tooth decay is a prevalent and concerning public health issue that is
Water fluoridation is considered one of the top ten greatest health achievements of the twentieth century due to its effectiveness in reducing the prevalence of dental caries. However, despite extensive research on the subject, there is little information currently available about how the constituents of drinking water affect the uptake...
Many students at the undergraduate level struggle with finding a niche that satisfies their various interests, specifically those in the arts and sciences. This study examined via interviews with fourteen current or recently graduated Oregon State Students, along with my own experience at the University, how students define art and...
Methodologies that detect biologically active substances have important potential applications for medical diagnostics, drug discovery, and chemical and biological anti-terrorism efforts. The wide spectrum of potential analytes that induce a physiological response dictates that novel techniques be developed to more rapidly screen and characterize agents that are more economical and...
Every cell is faced continuously with the task of transducing a vast number of external signals into appropriate intracellular responses. In mammalian cells, membrane bound receptors modulate the production of secondary messenger molecules, such as cyclic AMP (cAMP). Cell signaling through second messengers relies on the diffusion of such second...
Blood vessel injury was found to release intracellular pools of protein
D-aspartyl/L-isoaspartyl carboxyl methyltransferase (PIMT) into the extracellular
milieu, where it became trapped. Trapped PIMT was able to utilize radiolabeled
S-adenosyl-L-methionine (AdoMet) introduced into the circulation to methylate
blood vessel proteins containing altered aspartyl residues specifically at the site
of...
This thesis explores the feasibility of using melanophore-based biosensors from Oreochromis niloticus. Melanophores are one type of pigmented cell of the scales and fins of fish that respond in a motile fashion to a diverse range of stimuli. Fish scales were employed as the first step in determining the utility...
This is the first study to explore the ability of an enzyme to recognize and repair
spontaneous age-dependent damage to its own sequence. Protein (D-aspartyl/L-isoaspartyl)
carboxyl methyltransferase (PCM) is known to repair damage that arises
from a spontaneous isomerization of aspartyl and asparaginyl residues in other proteins
during aging. As...