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NhaP1 is a K+(Na+)/H+ antiporter required for growth and internal pH homeostasis of Vibrio cholerae at low extracellular pH

Creator:: Quinn, Matthew J., Resch, Craig T., Sun, Jonathan, Lind, Erin J., Dibrov, Pavel, and Hase, Claudia C.
Abstract:: Vibrio cholerae has adapted to a wide range of salinity, pH and osmotic conditions, enabling it to survive passage through the host and persist in the environment. Among the many proteins responsible for bacterial survival under these diverse conditions, we have identified Vc-NhaP1 as a K+(Na+)/H+ antiporter essential for V....
Resource Type:: Article
Full Text:: untitled NhaP1 is a K+(Na+)/H+ antiporter required for growth

Molecular and genetic assessment of selected antiporters and methyl-accepting chemotaxis proteins in Vibrio cholerae

Creator:: Quinn, Matthew J.
Abstract:: The pathogen Vibrio cholerae uses cations as a primary currency of virulence and environmental persistence, using gradients of those cations to move, acquire nutrients, and control virulence gene expression. An understanding of the overlapping roles of bioenergetics and chemotaxis in the virulence and environmental survival of V. cholerae issues from...
Resource Type:: Dissertation
Full Text:: antiporter was found to be a K+(Na+)/H+ antiporter essential for V. cholerae growth at low environmental pH

Na +/H + Antiport Is Essential for Yersinia pestis Virulence

Creator:: Minato, Yusuke, Ghosh, Amit, Faulkner, Wyatt J., Lind, Erin J., Schesser Bartra, Sara, Plano, Gregory V., Jarrett, Clayton O., Hinnebusch, B. Joseph, Winogrodzki, Judith, Dibrov, Pavel, and Hase, Claudia C.
Abstract:: Na⁺/H⁺ antiporters are ubiquitous membrane proteins that play a central role in the ion homeostasis of cells. In this study, we examined the possible role of Na⁺/H⁺ antiport in Yersinia pestis virulence and found that Y. pestis strains lacking the major Na⁺/H⁺ antiporters, NhaA and NhaB, are completely attenuated in...
Resource Type:: Article
Full Text:: , Lind EJ, Dibrov P, Häse CC. 2012. NhaP1 is a K�(Na�)/H� antiporter required for growth and internal pH

Role of Na+/H+ Membrane Bioenergetics in Virulence Factors of Pseudomonas aeruginosa

Creator:: Hoang, Kelli H.
Abstract:: Pseudomonas aeruginosa is a bacterial pathogen that can cause grave and sometimes chronic infections in patients with weakened immune systems and cystic fibrosis. It is suspected that specialized sodium pumps in the cellular membrane are crucial for the organism’s survival and growth, since many cellular processes rely on the maintenance...
Resource Type:: Honors College Thesis
Full Text:: ]. Cases where ΔnuoB showed a greater area of growth than the wild type, such as at pH 6.5, 400 mM Na

GillonJacquelineJ2016_BRRThesis.pdf

Creator:: Gillon, Jacqueline and Schubiger, Carla
Abstract:: Vibrio cholerae (Vc), the etiological agent of cholera, has developed many mechanisms to combat the great fluctuations in pH, ion content and osmotic conditions of the vastly differing environments it encounters through its infections of the human host. A series of cation antiporters are found in the Vc membrane to...
Full Text:: , Hase CC. 2012. NhaP1 is a K+(Na+)/H+ antiporter required for growth and internal pH homeostasis of

GillonJacquelineJ2016_BRRSeminar.pdf

Creator:: Gillon, Jacqueline and Schubiger, Carla
Abstract:: Vibrio cholerae (Vc), the etiological agent of cholera, has developed many mechanisms to combat the great fluctuations in pH, ion content and osmotic conditions of the vastly differing environments it encounters through its infections of the human host. A series of cation antiporters are found in the Vc membrane to...
Full Text:: , nhaP1, nhaP2, and nhaP3, in combination, are required for the survival of Vibrio cholerae through the

Characterization of the Sodium Transporting NADH:Quinone Oxidoreductase (NQR) in Vibrio cholerae

Creator:: Fassio, Sara R.
Abstract:: Vibrio cholerae is the causative agent of cholera, a serious diarrheal disease in developing countries. V. cholerae has a unique redox driven respiration-linked sodium pump, Na⁺ translocating NADH:quinone oxidoreductase (NQR). Several reports previously showed that NQR plays an important role in virulence, metabolism, and sodium homeostasis of V. cholerae. This...
Resource Type:: Honors College Thesis
Full Text:: (500mM) (Fig. 6). Growth of a Na+/H+ antiporter mutant, ΔnhaA was normal and not affected by the

FassioSaraMicrobiologyRolesSodium-Translocating.pdf

Creator:: Minato, Yusuke, Fassio, Sara R., Kirkwood, Jay S., Halang, Petra, Quinn, Matthew J., Faulkner, Wyatt J., Aagesen, Alisha M., Steuber, Julia, Stevens, Jan F., and Häse, Claudia C.
Abstract:: The Na⁺ translocating NADH:quinone oxidoreductase (Na⁺-NQR) is a unique respiratory enzyme catalyzing the electron transfer from NADH to quinone coupled with the translocation of sodium ions across the membrane. Typically, Vibrio spp., including Vibrio cholerae, have this enzyme but lack the proton-pumping NADH:ubiquinone oxidoreductase (Complex I). Thus, Na⁺-NQR should significantly...
Full Text:: required for growth and internal pH homeostasis of Vibrio cholerae at low extracellular pH. Microbiology

Comparative genomics of Vibrio and characterizing microbial communities at a shellfish hatchery

Creator:: Delgado, Hanna
Abstract:: Vibrio bacteria are commonly found in freshwater, marine, and estuarine environments. Members of this genus can exist in commensal relationships with marine animals or as planktonic bacteria, however, they are well known for their roles as pathogens towards humans and animals. In this dissertation, I investigated aspects of host-bacteria relationships...
Resource Type:: Dissertation
Full Text:: Extracellular Metalloprotease of Vibrio tubiashii Is a Major Virulence Factor for Pacific Oyster (Crassostrea

Investigating Vibrio parahaemolyticus interactions with the Pacific oyster, Crassostrea gigas

Creator:: Aagesen, Alisha M.
Abstract:: Vibrio parahaemolyticus is a Gram-negative, halophilic, human pathogenic bacterium ubiquitous in the marine environment. Like many Vibrio species, V. parahaemolyticus commonly associates with shellfish, particularly oysters. Ingestion of a raw or under cooked oysters contaminated with V. parahaemolyticus can cause gastroenteritis, which is typically self-limiting and rarely causes death. Globally,...
Resource Type:: Dissertation
Full Text:: of pilA from Vibrio cholerae (A), Vibrio parahaemolyticus (B), and Vibrio vulnificus (C

ScholarsArchive@OSU

NhaP1 is a K+(Na+)/H+ antiporter required for growth and internal pH homeostasis of Vibrio cholerae at low extracellular pH

Molecular and genetic assessment of selected antiporters and methyl-accepting chemotaxis proteins in Vibrio cholerae

Na +/H + Antiport Is Essential for Yersinia pestis Virulence

Role of Na+/H+ Membrane Bioenergetics in Virulence Factors of Pseudomonas aeruginosa

GillonJacquelineJ2016_BRRThesis.pdf

GillonJacquelineJ2016_BRRSeminar.pdf

Characterization of the Sodium Transporting NADH:Quinone Oxidoreductase (NQR) in Vibrio cholerae

FassioSaraMicrobiologyRolesSodium-Translocating.pdf

Comparative genomics of Vibrio and characterizing microbial communities at a shellfish hatchery

Investigating Vibrio parahaemolyticus interactions with the Pacific oyster, Crassostrea gigas

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