Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with
a unique molecular architecture and pronounced biological activity, are described. These
studies resulted in the synthesis of advanced intermediate 208, containing all of the
carbon atoms of 1.
A Dötz annulation between alkyne 122 and novel chromium carbenoid...
An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
There are well over 200 species of fishes which are known to be venomous, and which are capable of inflicting serious and
potentially fatal wounds. Within this group, less than 5% have been studied even in the most preliminary manner and, to date, the
basic chemical structure of even a...
Thinning of young Douglas-fir forests has the potential to enhance structural diversity and improve habitat for wildlife. I examined the effects of thinning and thinning intensity on abundance and demographic characteristics of forest-floor small mammals in the Coast Range of Oregon 5 and 6 years after thinning had occurred. Thinning...
Growth phenology (i.e., timing of growth initiation and cessation) is important to adaptation. This study examined the extent of genetic control of bud and cambial phenology and their relationships with stem
growth in pole-size Douglas-fir (ages 13 to 16 years) from 60 open-pollinated families. The availability of bud phenology data...
Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
In this dissertation I study evolutionary patterns at genes encoding antimicrobial peptides (AMPs) in frogs. AMPs are short, amphipathic, cationic, secreted proteins that kill bacteria and other pathogens through a non-catalytic mechanism that involves
binding to and disrupting the microbial cell membrane. In many animal taxa, positive selection is much...
The purpose of this research is to study the
feasibility of combining reaction and separation in a
membrane separation unit. The asymmetric ceramic membrane
reactor applied to the gas-phase catalytic decomposition
reaction of ammonia from an IGCC (Integrated Gasification
Combined Cycle Processes) gas mixture was simulated in the
temperature range...
This study was conducted to investigate the possible contamination
of foreign pollen at different stages of a wheat breeding
program. These included spaced planted F₂ segregating populations,
replicated yield trials and seed multiplication. The experimental
wheat materials consisted of four different F₂ populations, four
cultivars and two experimental lines.
Two...
The Aucanquilcha Volcanic Cluster (AVC) is the erupted part of a magmatic system with a complex and long-lived history. The AVC lies at 21°S in the high Andes and is built on thick continental crust. The thick crust in the area combined with the prolonged magmatic activity make it an...