Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
, Catherine E. Peishoff, Susan Pieniazek, Randy J. Read, Chenghua Shao, Steven
Sheriff, OliverSmart, Stephen
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
. Peishoff,30 Susan Pieniazek,32 Randy J. Read,33
Chenghua Shao,5 Steven Sheriff,34 OliverSmart,21 Stephen
The focus of this grounded theory research was to investigate the problems that those groups closest to students placed in mathematics classes by mathematics ability have and how those parties work to resolve the problems. The main problem found was a conflict between educators and parents over which students deserve...
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intelligence can change over time (Archer, 1999; Oliver &
Licheveskivi, 1991; Schmidt & Kennedy, 1990
Conservation investment in management of at-risk species can be less costly than a delay-and-repair approach implemented after species receive legal protection. The United States Endangered Species Act candidate species designation represents an opportunity to implement proactive management to avoid future listing. Such efforts require substantial investments, and the challenge becomes...
Full Text:
., Walker, S., Wilson,
K.A., Possingham, H.P., 2008. Is conservation triage just smart decision making
Conservation investment in management of at-risk species can be less costly than a delay-and-repair
approach implemented after species receive legal protection. The United States Endangered Species
Act candidate species designation represents an opportunity to implement proactive management to
avoid future listing. Such efforts require substantial investments, and the challenge becomes...
Full Text:
., Walker, S., Wilson,
K.A., Possingham, H.P., 2008. Is conservation triage just smart decision making
Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a
role in exocytosis at hair cell ribbon synapses. To date however, otoferlin has been
studied almost exclusively in mouse models, and no rescue experiments have...
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query sequences. ClustalW and PRALINE tools were used for sequence 89
alignments. SMART and SWISS
Phellinus sulphurascens (previously the Douglas-fir form of Phellinus weirii) is an important native pathogen causing laminated root rot in forests of western North America. Visual crown symptoms, or attacks by bark or ambrosia beetles appear only during advanced stages of the disease with extensive infection in the lower bole. Ethanol...
Management of marine ecosystems increasingly demands comprehensive and quantitative assessments of ocean health,
but lacks a tool to do so. We applied the recently developed Ocean Health Index to assess ocean health in the relatively
data-rich US west coast region. The overall region scored 71 out of 100, with sub-regions...