Oregon's estuaries are important ecosystems for scientific study. Consequently, knowledge of what research has been conducted helps us identify benchmarks and plan new projects. A comprehensive bibliography of published research, technical reports, local documents, and data sets is one means of recording this knowledge. For these reasons, the Guin Library...
Programming is integrated across the workflow of multiple domains where end-user programmers, those who need to program as a means to an end, regularly need to code. In the modern setting of collaborative development, end-user programmers have to interpret the intentions behind existing code to contribute and build solutions to...
Immobilized proteins are integral components of a number of important technologies, including the principal component of many biosensors, as functional coatings in various implants, as catalysts is industrial biosynthesis, and as the building blocks of next-generation nanotechnologies. Despite their ubiquity, relatively little is known about the processes that shape immobilized...
Climate change is a global phenomenon, but natural selection occurs within landscapes. A central tenet of landscape ecology is that mobile species depend on complementary habitats, which are insufficient in isolation, but combine to support animals through the full annual cycle. For coldwater fishes, it is widely assumed that maximum...
Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics.
Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
The rapid accumulation of polyethylene terephthalate (PET) plastic waste caused by disposable plastic water bottle use is a worldwide problem that will continue to affect our environment, economy and society unless new methods of reduction and degradation are explored. The large amounts of energy and resources that are required during...
Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
In this dissertation, I describe the experimental investigation of large superfluid helium droplets. The goal and direction of this thesis is to facilitate the use of these droplets as part of our project ss-EDI. The overall scheme of ss-EDI is to dope proteins inside helium droplets and collect a diffraction...
The Olympia oyster is a foundation species that increases habitat structure for associate species in estuarine systems of the Pacific Coast of North America (Kimbro & Grosholz, 2006). This oyster provides ecosystem services in the form of water filtration (zu Ermgassen et al., 2013), habitat for commercially valuable species such...
Leukemogenesis, uncontrolled proliferation of dysfunctional, transformed immature lymphocytes, appears, especially in children, to be associated with abrogation of normal lymphopoiesis, and thymopoiesis in the case of T cell leukemias. Sequence specific transcription factors (SSTFs) are nuclear control switches that respond to cellular signals to alter cell state and cell fate...