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The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

Creator:: Miller, Galen W., Ulatowski, Lynn, Labut, Edwin M., Lebold, Katie M., Manor, Danny, Atkinson, Jeffrey, Barton, Carrie L., Tanguay, Robert L., and Traber, Maret G.
Abstract:: The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring...
Resource Type:: Article
Full Text:: . (2012) The a-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis. PLoS ONE 7(10

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Creator:: Miller, Galen W.
Abstract:: Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
Resource Type:: Dissertation
Full Text:: TRANSFER PROTEIN IS ESSENTIAL FOR VERTEBRATE EMBRYOGENESIS ................................ 115! Abstract

Embryogenesis is dependent upon 12-lipoxygenase, 5-lipoxygenase, and alpha-tocopherol to modulate polyunsaturated fatty acid status and the production of oxidized fatty acids in zebrafish, Embryogenesis is dependent upon 12-lipoxygenase, 5-lipoxygenase, and α-tocopherol to modulate polyunsaturated fatty acid status and the production of oxidized fatty acids in zebrafish

Creator:: Lebold, Katherine M.
Abstract:: Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are polyunsaturated fatty acids required for proper embryonic development, specifically neurodevelopment. However, little is known regarding their conversion to other metabolites during embryogenesis. The oxidation of ARA gives rise to the biologically active eicosanoids and the oxidation of DHA gives rise to the...
Resource Type:: Masters Thesis
Full Text:: is required for proper embryonic development. Additionally, we hypothesize that α-tocopherol, a

Impact of Vitamin E Deficiency on Hepatic Gene Expression of CRAL_TRIO Family Proteins in a Premier Vertebrate Animal Model

Creator:: Watt, Alexander T.
Abstract:: Vitamin E (vitE) is a group of lipid-soluble antioxidants- of which alpha-tocopherol is the most biologically active and only form considered to be an essential nutrient. Through preferential binding and trafficking, the alpha-tocopherol transfer protein (α-TTP) regulates the concentration of vitE in the body. The impact of vitE deficiency on...
Resource Type:: Honors College Thesis
Full Text:: the liver, α-TTP is responsible for the transfer of alpha-tocopherol to very-low-density lipoprotein

Investigating Protein-lipid-membrane Interactions in Plant Cells using Bimolecular Fluorescence Complementation

Creator:: Tao, Kai
Abstract:: The overall focus of this thesis is on the distribution of specific lipids and membrane proteins of the external and internal membranes of plant cells, in the context of the roles that those lipids and proteins may play in microbe-plant interactions. The work includes the development of several new tools,...
Resource Type:: Dissertation
Full Text:: amphipathic loop at the very C-terminus is necessary and sufficient for PM binding (Perraki et al., 2012

The genetic dissection of the fruitless gene's functions during embryogenesis in Drosophila melanogaster

Creator:: Song, Ho-Juhn
Abstract:: The fruitless (fru) gene in Drosophila melanogaster is a multifunctional gene having sex-specific functions in the regulation of male sexual behavior and sex-nonspecific functions affecting adult viability and external morphology. While much attention has focused on fru's sex-specific roles, little is known about its sex-nonspecific functions. The embryonic central nervous...
Resource Type:: Dissertation
Full Text:: role since it is responsible for the asymmetric distribution of Numb protein into one of the sibling

Protein Disorder in the Evolution of Dynein Regulation

Creator:: Jie, Jing
Abstract:: Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
Resource Type:: Dissertation
Full Text:: that the N-Pac11 is primarily disordered except for an N-terminal single alpha helix (SAH) and

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Creator:: Sengupta, Sumitra
Abstract:: Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
Resource Type:: Dissertation
Full Text:: , therapeutic approaches allowing the regenerative replacement of damaged tissues is essential for the

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Creator:: Chatterjee, Paroma
Abstract:: Auditory defects and disorders are prevalent at all ages and affect 8% of the population in developed nations including newborns and children. Congenital hearing loss is the most common birth defect and it is estimated that 1 in 1000 children are affected by deafness at birth or before the onset...
Resource Type:: Dissertation
Full Text:: Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing. Abstract approved

Effects of various protease inhibitors on protein degradation of cultured myotubes

Creator:: Wu, Paiyen
Resource Type:: Masters Thesis
Full Text:: is responsible for at least the initial step or the rate-regulating step of myofibrillar protein

ScholarsArchive@OSU

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Impact of Vitamin E Deficiency on Hepatic Gene Expression of CRAL_TRIO Family Proteins in a Premier Vertebrate Animal Model

Investigating Protein-lipid-membrane Interactions in Plant Cells using Bimolecular Fluorescence Complementation

The genetic dissection of the fruitless gene's functions during embryogenesis in Drosophila melanogaster

Protein Disorder in the Evolution of Dynein Regulation

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Effects of various protease inhibitors on protein degradation of cultured myotubes

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