Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
In my view, ecocriticism needs a foundation in something akin to metaphysics. This work in progress began as an effort to find such a foundation. In the course of working on it, I discovered philosophers today, mostly young, clearly a new generation, philosophizing under the umbrella term “speculative realism” what...
The development and some applications of holographic optical tweezers (HOT) are presented. Our HOT system uses a spatial light modulator (SLM) to control the location and properties of the optical trap. We have developed a method for optimizing the diffraction efficiency of a SLM that can be applied in situ...
Given the current abundant supply and cheap price of natural gas (NG) in the United States, there is a significant opportunity to use this fuel for transportation. However, there are few fueling stations for consumers. To address this need, a dual-mode engine has been developed where in one mode all...