DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
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. Depner , CarmenP. Wong, and Donald B. Jump 1
Nutrition Program, School of Biological and
DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
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; *,
p<0.05 versus RD; #, p<0.05 versus WD + O.
Literature cited.
1. Jump, D. B., M. Torres
Introduction. Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the...
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tools, wrote the paper, prepared figures and/or tables,
reviewed drafts of the paper.
• CarmenP. Wong
Introduction. Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the...
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means using Wilcoxon Rank Sum Test with q-value FDR multiple test correction. Taxa with p < 0.05 and q
Introduction. Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the...
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in 50% of samples. Kendall Tau Correlation Coefficients, along with corresponding p-values and q
Native to the Pacific Northwest, Ceratomyxashastais a myxosporeanparasite that infects wild and cultivated salmon and has a significance impact on its population in the Klamath River basin. The study suggests that the transmission of mixed genotypes of the parasite are common in Chinook salmon but the age of the fish...
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, Ceratomyxa shasta
Transmission and
Persistence of
Ceratomyxa shasta in
Chinook Salmon
P E T E R WO N G
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in
carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive
agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor
suppressor genes silenced...
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Epithelial Cells and Prostate Cancer Cells
CarmenP. Wong1,2, Anna Hsu1,2, Alex Buchanan1, Zoraya Palomera
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in
carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive
agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor
suppressor genes silenced...
BACKGROUND: The impact of cell-composition effects in analysis of DNA methylation data is now widely appreciated.
With the availability of a reference data set consisting of DNA methylation measurements on isolated cell types, it is
possible to impute cell proportions and adjust for them, but there is increasing interest in...
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E Andres Houseman1*, Karl T Kelsey2, John K Wiencke3 and Carmen J Marsit4
Abstract
Background: The
BACKGROUND: The impact of cell-composition effects in analysis of DNA methylation data is now widely appreciated.
With the availability of a reference data set consisting of DNA methylation measurements on isolated cell types, it is
possible to impute cell proportions and adjust for them, but there is increasing interest in...
Full Text:
. Kelsey, John K. Wiencke, Carmen J. Marsit
Figure S1
Number of significant kΒ coefficients (q