The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
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obesity-related metabolic dysfunction
Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling
exclusively in intestine, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:
obesity-related metabolic dysfunction
Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., & Gonzalez, F. J
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling
exclusively in intestine, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Chromosomal rearrangements may complicate construction of Arabidopsis with multiple TDNA-insertion mutations. Here, crossing two lines homozygous for insertions in AtREV3 and AtPOLH (chromosomes I and V, respectively) and selfing F1 plants yielded non-Mendelian F2 genotype distributions: frequencies of +/++/+ and 1/1 2/2 progeny were only 0.42 and 0.25%. However, the...
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Fluorescence in situ hybridization
RB
T-DNA right border
LB
T-DNA left border
CEN
Centromere
LETEL
Left
The Kenyan-Tanzanian coastal region in the western Indian Ocean faces several environmental challenges including coral reef conservation, fisheries management, coastal erosion, and nearshore pollution. The region lacks hydrodynamic records and oceanographic studies at adequate spatial and temporal scales to provide information relevant to the local environmental issues. We have developed...
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Rai, 2008; Mishra et al., 2007; Xie et al., 2002; Lee and Marotzke, 1998; Anderson
et al., 1991] that
Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs...
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, Peng L, Fang X, Yin X, Xu N, Cen P (2006) Recent advances in the
research and development of human
Simulations from a regional climate model (RCM) as part of a superensemble experiment were compared with observations of surface meteorological variables over the western United States. The RCM is the Hadley Centre Regional Climate Model, version 3, with improved physics parameterizations (HadRM3P) run at 25-km resolution and nested within the...
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(Harris et al. 2014).
The fifth dataset was the Climate Prediction Cen-
ter (CPC) 0.258 3 0.258 daily
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine.
The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote
DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
Signal transduction within and between cells is at the core of biological activity in all living systems. Signaling networks are required for regulating biological functions, including growth, development and survival. Deregulation of signaling cascades has been linked to chronic and acute diseases and disorders This thesis focuses on mass spectrometry...