The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:
obesity-related metabolic dysfunction
Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Warmer SST and more rain in the Northern Hemisphere are observed year-round in the tropical eastern Pacific with southerly wind crossing the equator toward the atmospheric heating. The southerlies are minimal during boreal spring, when two precipitation maxima straddle the equator. Fourteen atmosphere–ocean coupled GCMs from the Coupled Model Intercomparison...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling
exclusively in intestine, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:
obesity-related metabolic dysfunction
Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., & Gonzalez, F. J
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling
exclusively in intestine, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The midsummer drought (MSD) is a diminution in rainfall experienced during the middle of the rainy season in southern Mexico and Central America, as well as in the adjacent Caribbean, Gulf of Mexico, and eastern Pacific seas. The aim of this paper is to describe the regional characteristics of the...
Recent observations from spaceborne microwave sensors have revealed detailed structure of the surface
flow over the equatorial eastern Pacific in the boreal fall season. A marked acceleration of surface wind
across the northern sea surface temperature (SST) front of the cold tongue is a prominent feature of the
regional climate....
The tropical Pacific Ocean is a climatically important region, home to El Niño and the Southern Oscillation. The simulation of its climate remains a challenge for global coupled ocean–atmosphere models, which suffer large biases especially in reproducing the observed meridional asymmetry across the equator in sea surface temperature (SST) and...