BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
Full Text:
Guidelines. New England Journal of Medicine, 372(5),
447-455. doi:10.1056/NEJMsa140675110.1056
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
Full Text:
. N Engl J Med 2015;372:447-55. DOI: 10.1056/NEJMsa1406751
(PDF updated March 9, 2015
The Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO-CBRND) began development of a broad-spectrum antiviral countermeasure against deliberate use of high-consequence viral hemorrhagic fevers (VHFs) in 2016. The effort featured comprehensive preclinical research, including laboratory testing and rapid advancement of lead molecules into nonhuman primate (NHP)...
The most frequent cause of pseudomembranous colitis is Clostridium difficile (C. difficile) infection. This type of colitis is characterized by an endoscopic pattern of numerous small, yellowish or whitish plaques diffusely distributed, which typically compromises the rectum extending to proximal colon. Occasionally, the pseudomembranes compromise only the transverse or right...
INTRODUCTION: Between 2004 and 2010, the number of home births in the United States rose by 41%, increasing the need for accurate assessment of the safety of planned home birth. This study examines outcomes of planned home births in the United States between 2004 and 2009.
METHODS: We calculated descriptive...
Full Text:
delivery. N
Engl J Med. 2004;351(25):2581–2589. doi:10.1056/NEJMoa040405.
8.MacdormanMF, Kirmeyer S. The
The increased severity of Clostridium difficile infection is primarily attributed to the appearance of an epidemic strain characterized as PCR ribotype 027. The only report that identified epidemic C. difficile ribotype 027 in an American country outside of North America comes from Costa Rica, raising the possibility that strains 027...
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:
Medicine, 373(4), 339-348.
doi:10.1056/NEJMoa1410345
10.1056/NEJMoa1410345
Massachusetts Medical Society
Background:
As Zika virus continues to spread, decisions regarding resource allocations to control the
outbreak underscore the need for a tool to weigh policies according to their cost and the
health burden they could avert. For example, to combat the current Zika outbreak the US
President requested the allocation of...
Full Text:
://www.nejm.org/doi/full/10.1056/NEJMoa1602412
7. WHO | Microcephaly–Panama. World Health Organization; 2016
Background—The effect of intensive blood pressure (BP) lowering on kidney function among individuals with established cerebrovascular disease and preserved estimated glomerular filtration rate (eGFR) is not established.
Methods and Results—Among 2610 participants randomized to a lower (<130 mm Hg) versus higher (130–149 mm Hg) systolic BP target with repeated measures...
Full Text:
kidney disease. N Engl J Med.
2010;363:918–929. doi: 10.1056/NEJMoa0910975.
7. Upadhyay A, Earley A
Estrogen (E2) is essential for multiple physiological effects in females, ensuring maximum reproductive fitness and maintaining skeletal homeostasis. E2 has been shown to stimulate cancellous bone formation via activation of estrogen receptor alpha (ERα), an effect widely accepted to be mediated directly at bone. A recent landmark study by Herber...