Certain 2- chioroethyl nitrosoureas have been demonstrated
to be highly specific inactivators of chymotrypsin
in vitro and glutathione reductase, both in vivo and in
isolated rat hepatocytes. The inactivation of glutathione
reductase in isolated hepatocytes resulted in an increased
sensitivity toward an adriamycin induced oxidative
challenge.
Prolonged incubation of 1-(2-chloroethyl)-3-([1-¹⁴...
Core-collapse supernovae (CCSNe) are considered to be important contributors to the primitive dust enrichment of the interstellar medium in the high-redshift universe. Theoretical models of dust formation in stellar explosions have so far provided controversial results and a generally poor fit to the observations of dust formation in local supernovae....
We study the late-time (t > 0.5 days) X-ray afterglows of nearby (z < 0.5) long gamma-ray bursts (GRBs) with Swift and identify a population of explosions with slowly decaying, super-soft (photon index Γx > 3) X-ray
emission that is inconsistent with forward shock synchrotron radiation associated with the afterglow....
The HIV pandemic continues to impose enormous morbidity, mortality and economic burdens across the globe. Simultaneously, innovations in antiretroviral therapy, diagnostic approaches and vaccine development are providing novel tools for treatment-as-prevention and prophylaxis. We developed a mathematical model to evaluate the added benefit of an HIV vaccine in the context...
In two studies we tested the effect of vitamin B-6
(B-6) intake on in vitro lymphocyte, proliferation and IL-2
production in healthy young women. In Study I, 6 women were
fed a constant diet containing 0.84 mg (4.96 μmols) of B-6
for 12 d, and 1.24 mg (7.33 μmols) and...
The binding energies of n < 100 carbon clusters are calculated using the ab initio density functional theory code
Quantum Espresso. Carbon cluster geometries are determined using several levels of classical techniques and further
refined using density functional theory. The resulting energies are used to compute the work of cluster...
The HIV pandemic continues to impose enormous morbidity, mortality and economic burdens across the globe. Simultaneously, innovations in antiretroviral therapy, diagnostic approaches and vaccine development are providing novel tools for treatment-as-prevention and prophylaxis. We developed a mathematical model to evaluate the added benefit of an HIV vaccine in the context...