Index Catalog // ScholarsArchive@OSU

Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

Creator:: Nosal, Daniel Grzegorz
Abstract:: Superwarfarins are anticoagulant rodenticides that are 100 times more potent and 15 times more persistent than warfarin. They have been used since the 1980s and cause over 10,000 cases of accidental and intentional poisonings per year. Apart from inducing uncontrollable bleeding, by inhibiting the vitamin K cycle, superwarfarins can disrupt...
Resource Type:: Dissertation
Full Text:: , Chicago, IL 60612, USA J. AOAC. Int., 2020, 103(3), 770 – 778 DOI: 10.1093/jaoacint

BissonWilliamHEnvironmentalMolecularToxicologyMetabolicReprogrammingDysregulated.pdf

Creator:: Robey, R. Brooks, Weisz, Judith, Kuemmerle, Nancy, Bisson, William H., and et al.
Abstract:: Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of individual agents at singular endpoints. As such, they have incompletely addressed both the pro-carcinogenic contributions of environmentally...
Full Text:: of environmental carcinogenesis?. Carcinogenesis, 36(Suppl 1), S203-S231. doi:10.1093/carcin/bgv037

ASRP: the Arabidopsis Small RNA Project Database

Creator:: Gustafson, Adam M., Allen, Edwards, Givan, Scott, Smith, Daniel, Carrington, James C., and Kasschau, Kristin D.
Abstract:: ABSTRACT Eukaryotes produce functionally diverse classes of small RNAs (20–25 nt). These include microRNAs (miRNAs), which act as regulatory factors during growth and development, and short-interfering RNAs (siRNAs), which function in several epigenetic and post-transcriptional silencing systems. The Arabidopsis Small RNA Project (ASRP) seeks to characterize and functionally analyze the...
Resource Type:: Article
Full Text:: , Database issue D637–D640 doi:10.1093/nar/gki127 composed of web pages delivered by an apache HTTP

SEK: sparsity exploiting k-mer-based estimation of bacterial community composition

Creator:: Chatterjee, Saikat, Koslicki, David, Dong, Siyuan, Innocenti, Nicholas, Cheng, Lu, Lan, Yueheng, Vehkaperä, Mikko, Skoglund, Mikael, Rasmussen, Lars, K., Aurell, Erik, and Corander, Jukka
Abstract:: MOTIVATION: Estimation of bacterial community composition from a high-throughput sequenced sample is an important task in metagenomics applications. Since the sample sequence data typically harbors reads of variable lengths and different levels of biological and technical noise, accurate statistical analysis of such data is challenging. Currently popular estimation methods are...
Resource Type:: Article
Full Text:: . Bioinformatics, 30(17), 2423-2431. doi:10.1093/bioinformatics/btu320 10.1093/bioinformatics/btu320 Oxford

Social segregation of humpback whales in contrasted coastal and oceanic breeding habitats

Creator:: Derville, Solène, Garrigue, Claire, and Torres, Leigh G.
Abstract:: Article available for download at publisher's website: https://doi.org/10.1093/jmammal/gyx185
Resource Type:: Article

Gene-silencing antisense oligomers inhibit Acinetobacter growth in vitro and in vivo

Creator:: Geller, Bruce L., Marshall-Batty, Kimberly, Schnell, Frederick J., McKnight, Mattie M., Iversen, Patrick L., and Greenberg, David E.
Abstract:: Background: Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA/RNA analogs that silence expression of specific genes. We studied whether PPMOs targeted to essential genes in Acinetobacter lwoffii and A. baumannii are active in vitro and in vivo. Methods: PPMOs were evaluated in vitro using MIC and viability assays, and in...
Resource Type:: Article

Krill biomass and aggregation structure in relation to tidal cycle in a penguin foraging region off the Western Antarctic Peninsula

Creator:: Bernard, Kim S. and Steinberg, Deborah K.
Abstract:: Antarctic krill are a key component of the diet of Adélie penguins inhabiting the Western Antarctic Peninsula (WAP), yet our understanding of the variability of krill distribution patterns within nearshore penguin feeding grounds is limited. A recent study of the foraging patterns of penguins breeding in the northern WAP suggests...
Resource Type:: Article

Soot Modeling: GPU Accelerated Direct Simulation Monte Carlo

Creator:: Lorson, Paige
Abstract:: For this project, we designed a soot modeling software to produce a full particle density function. This model uses the Direct Simulation Monte Carlo with a full conditioning particle selection method to capture soot nucleation and coagulation in a diffusion flame. We investigate the use of graphic processing units as...
Resource Type:: Capstone Project
Full Text:: / carcin/22.5.741. url: https://doi.org/10.1093/carcin/22.5.741 (visited on 12/04/2021). [11] Daniel T

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Creator:: Luo, Yun L.
Abstract:: Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Resource Type:: Honors College Thesis
Full Text:: . Carcinogenesis, 26(6), 1158-1158. doi:10.1093/carcin/bgi099 Duan, X., Shen, G., Yang, H., Tian, J., Wei, F

Sampson_BRR_Seminar.pptx

Creator:: Sampson, David
Abstract:: Lung cancer in humans is an adult-onset disease. It is the number one cause of cancer mortality for both men and women and has a poor (15%) survival rate. Biological markers of the disease would allow for early diagnosis and treatment. The specific aims of this research project were to...
Full Text:: ://doi.org/10.1093/carcin/bgl072 Yu, Z., Loehr, C. V., Fischer, K. A., Louderback, M. A., Krueger, S. K

ScholarsArchive@OSU

Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

BissonWilliamHEnvironmentalMolecularToxicologyMetabolicReprogrammingDysregulated.pdf

ASRP: the Arabidopsis Small RNA Project Database

SEK: sparsity exploiting k-mer-based estimation of bacterial community composition

Social segregation of humpback whales in contrasted coastal and oceanic breeding habitats

Gene-silencing antisense oligomers inhibit Acinetobacter growth in vitro and in vivo

Krill biomass and aggregation structure in relation to tidal cycle in a penguin foraging region off the Western Antarctic Peninsula

Soot Modeling: GPU Accelerated Direct Simulation Monte Carlo

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Sampson_BRR_Seminar.pptx

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