The olfactory bulb contains the first synaptic relay in the olfactory pathway, the sensory system in which odorants
are detected enabling these chemical stimuli to be transformed into electrical signals and, ultimately, the perception
of odor. Acid-sensing ion channels (ASICs), a family of proton-gated cation channels, are widely expressed in...
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-induced retinal degeneration. J. Neurosci. 24:1005–
1012. http://dx.doi.org/10.1523/JNEUROSCI.4698-03.2004
The cysteine-rich protein (CRP) family is a subgroup of LIM domain proteins. CRP1, which cross-links actin filaments to make actin bundles, is the only CRP family member expressed in the CNS with little known about its function in nerve cells. Here, we report that CRP1 colocalizes with actin in the...
With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Prior research has demonstrated that unique and salient objects in a visual display may capture an individual’s attention. However, researchers have shown that some individuals, such as those with video game experience, are better at resisting salient-driven capture compared to others (Chisholm et al., 2010). The first manuscript presented in...
Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an
expression level-dependent phenotype in transgenic rodents. We show that oral treatment with the therapeutic agent diacetyl-bis(4-methylthiosemicarbazonato)copper[superscript II] [Cu[superscript II](atsm)] increased the concentration of mutant SOD1 (SOD1G37R) in ALS model mice, but paradoxically improved locomotor...
Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
While human tool-use proficiency helped define our history, the cognitive and perceptual mechanics of how humans use tools are not fully understood. This question is of great value to the design of hand-held tools and prosthetics. A prominent theory, tool embodiment, suggests that tool use is facilitated by a flexible...
A significant proportion of the population of the United States suffers from chronic pain, a category of disease that is not yet well understood by healthcare professionals. A majority of this group is made up of women; individuals who often have to convince healthcare professionals that their symptoms are real...
Humans and rodents experience declines in reference (long-term) and working (short-term)
memory and cognitive flexibility during the aging process. Aging changes in GluN1 and
GluN2B subunits of N-methyl-D-aspartate (NMDA) receptors show a relationship to both
reference and working memory deficits. Sulindac, an anti-inflammatory drug, enhances working memory and NMDA receptor...
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12300–12305. doi:10.1523/JNEUROSCI.0312-13.2013
22. Sorge RE, Martin LJ, Isbester KA, Sotocinal SG