Two identical single-ascending-dose studies evaluated the safety and pharmacokinetics (PK) of AVI-6002 and AVI-6003, two experimental combinations of phosphorodiamidate morpholino oligomers with positive charges (PMOplus) that target viral mRNA encoding Ebola virus and Marburg virus proteins, respectively. Both AVI-6002 and AVI-6003 were found to suppress disease in virus-infected nonhuman primates...
Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense molecules that are able to target mRNAs...
In this issue of The Condor: Ornithological Applications, Haig et al. (2014) summarize negative impacts of lead ammunition and fishing tackle on birds and discuss strategies for mitigating risks to wildlife and human health. Their Review raises an important set of questions for hunters, wildlife managers, and conservation scientists. Effective...
Two new studies revealed unknown long-distance dispersal and migration movements in sage grouse that offer fresh insights for conservation. Using DNA from feathers dropped at leks, scientists discovered that some grouse (about 1% of populations) travel long distances to explore breeding areas up to 120 miles away—movements that can potentially...
Body size is known to correlate with many aspects of life history in birds, and this knowledge can be used to manage and conserve bird species. However, few studies have compared the wintering ecology of sympatric subspecies that vary significantly in body size. We used radiotelemetry to examine the relationship...
Potential for large prairie remnants to provide habitat for grassland-obligate wildlife may be compromised by
nonsustainable range-management practices. In 1979–1980, high nesting densities of 3 species of hawks in the genus
Buteo—Ferruginous Hawk (Buteo regalis), Red-tailed Hawk (B. jamaicensis), and Swainson’s Hawk (B. swainsoni)—were
documented on the Zumwalt Prairie and...
Studying the ecology of endangered species in portions of their range where the population remains abundant can
provide fundamental information for conservation planners. We studied nesting by radio-tagged Marbled Murrelets
(Brachyramphus marmoratus) during 2007 and 2008 in Port Snettisham, a relatively pristine, remote mainland fjord in
southeast Alaska with high...
Sometime in the early Mississippian, huge blocks
broke off the toe of the advancing Roberts Mountains
thrust and fell into the flysch trough. Within the thesis
area, the largest blocks are the Webb/Woodruff blocks,
which are composed of Devonian Woodruff Formation thrust
over Mississippian Webb Formation. The blocks came to...
Full Text:
7537 (Plate 1) matching
the type description, but its stratigraphic position is
uncertain.
Map units
Many exotic annual grasses are believed to increase wildfire frequency to the detriment of native vegetation
by increasing fine fuels and thus, creating a grass-fire cycle. However, information on differences in fuel characteristics
between invaded and non-invaded plant communities is lacking, or is based mainly on speculation and anecdotal evidence....