Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
Pactamycin, produced by the soil bacterium Streptomyces pactum, is a cytotoxic antibiotic that belongs to the aminocyclitol family of natural products. This antibiotic has shown various forms of biological activity, including antibacterial, antifungal, antimalarial, and antitumor activities. Despite its outstanding biological activity, the mode of formation of its pharmacophore (the...
Prediction intervals for an outcome of a sufficient statistic, T[subscript y], associated with the probability distribution of a future experiment are developed based on information obtained from n independent, previously conducted trials of an informative experiment. The random outcomes of the informative and future experiments are assumed to be continuous...
With ever-increasing number of vehicles actively using the state and national roadway network, transportation-related fuel consumption and consequent pavement structural damage rises. In this dissertation, the impact of material-induced dissipated energy mechanisms in asphalt and concrete pavements were analyzed using field measurements in California and finite element modeling of pavement...
Post stratification is considered desirable in sample surveys for two
reasons - it reduces the mean squared error when averaged over all possible
samples, and it reduces the conditional bias when conditioned on stratum
sample sizes. The problem studied in this thesis is post stratified estimation
of a finite population...
Bridges are a vital component of transportation infrastructure in the United States, and the continual maintenance and preservation of bridges is critical to maintaining their structural capacity and maximizing service life. One of the most significant issues faced by concrete bridges is the infiltration of moisture from the roadway surface...
Machine learning encompasses probabilistic and statistical techniques that can build models from large quantities of extensional information (examples) with minimal dependence on intensional information (domain knowledge). This focus of machine learning is reflected in the never-ending quest for "off-the-shelf" classifiers. To generalize to unseen data, however, we must make use...
Italian nationalism and an ‘Italian’ identity were constructed during Italy’s unification movement in the mid 1800’s. However, consensus on a national identity is still weak across Italy today. Instead, a polarization of Northern and Southern regions have contributed to discrimination, institutional racism and exclusion. This thesis demonstrates the multifaceted aspects...
The goal of this study was to better understand stream communities through a perspective that might make their structure, organization, and development more understandable. This goal was approached
through the following objectives:
1. To determine the assemblages of stream organisms and define subsystems within a stream community.
2. To explain...
Sporadic outbreaks of diacetyl off-flavor in beer are a serious
economic problem to the brewing industry. Studies were carried out
in an attempt to improve the understanding of the problem and to experiment
with new ways of controlling this defect.
The Owades and Jakovac method of diacetyl determination as
modified...