Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
The Earth is warming at a seemingly unstoppable rate, a virus is ravaging the world, and international tensions are ever-present. This brings me to wonder, how will we survive in the future? And as an artist that question turns into: what will we look like in the future? Partnered with...
The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
The discovery of novel compounds with antibacterial properties continues to be critically important.3 One potential source of such compounds is the cryptic genome of fungi known to produce biologically active molecules. A kmt6 mutant of the cereal pathogen Fusarium graminearum was previously developed through a histone H3 lysine 27 methyltransferase...
Endophytes are bacteria or fungi that live within a host plant. The plant host provides a home for endophytes, and in return endophytes produce primary and secondary metabolites, of which many of the secondary metabolites possess biological activities. When microorganisms are grown under various media conditions, they produce different natural...
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Overacker
DonovonAdpressa
Chenxi (Zoe) Zhu
Department of Microbiology
Oregon State University
Coral reefs form vast ecosystems in tropical oceans that are hotspots for biodiversity and are economically valuable. The ecological success of coral reefs is made possible by the symbiotic relationship between corals and dinoflagellate algae from the family Symbiodiniaceae. In this symbiosis, the algae are found within host gastrodermal cells...
Endophytes are bacteria or fungi that live within a host plant. The plant host provides a home for endophytes, and in return endophytes produce primary and secondary metabolites, of which many of the secondary metabolites possess biological activities. When microorganisms are grown under various media conditions, they produce different natural...
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here today. My name is Andrew Pham and I am now a senior in micro.
I currently research for Dr. Sandra
Tuberculosis (TB) is a pressing global health issue with approximately one third of the world’s population infected by this bacterium. As one of the most dangerous infectious diseases, it has killed approximately 1.7 million people of all ages around the world per year (World Health Organization, 2016). Currently, several drugs...
Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...