Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...
Memory is essential to everyday life. As we age, deficits in memory become apparent. The toll of age-related cognitive impairment can be devastating to families and costly to society. The NMDA receptor is a molecule in the brain that is instrumental in the formation of memories. The receptor is particularly...
Recent experimental and theoretical work has examined the possible genetic causes of senescence. These are reviewed, and four types of factors are found to be responsible for the evolution of senescence and age specific fecundity curves: 1. Age specific mortality schedules, 2.Density dependent factors, 3. Density independent factors, 4. Random...
Hybridization, polyploidy, and apomixis have made phylogenetic estimation in Rubus challenging. I used target capture to sequence approximately 1000 low copy nuclear loci and the chloroplast genome for 94 accessions representing the genus Rubus and distributed worldwide. Species phylogenies were estimated using two coalescent based methods, ASTRAL-II and SVDQuartets, and...
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Molecular Markers for Phylogenetic Analyses in Rubus
The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Proteinase P-II purified from parasitized Pacific whiting muscle was previously
identified to be one form of cathepsin L. It appeared to be present in three isozymatic
forms on non-denaturing PAGE gel stained for activity. Its autolytic degradation was
observed on SDS-PAGE gel under its optimum condition, 55°C and pH 5.5,...
In this dissertation, I present the results from three studies: (1) a phylogeny of Tenebrionoidea (Coleoptera) inferred from a seven-gene dataset derived from PCR and Sanger sequencing; (2) a phylogeny of Tenebrionidae, the largest family in Tenebrionoidea, inferred from a four-gene dataset also derived from PCR and Sanger sequencing; (3)...
Historical concepts of Clavicipitaceae have included a broad range of species that display diverse morphologies, ecological modes and host associations. When subjected to multigene phylogenetic investigation of evolutionary history, the family was found to be polyphyletic, largely driven by diversity in the genus Cordyceps, previously containing over 400 taxa. The...
Overall wood density is a complex trait resulting from the interaction of three components: average earlywood density, average latewood density, and latewood proportion. In order to better understand the genetic control of wood density in juvenile Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco), and to assess the utility of
information on its...
