Glutathione (GSH) is the predominant low molecular weight thiol antioxidant
in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox
ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
We examined the effect of daily stress, age, and emotional stability/neuroticism on stress reactivity, using cortisol diurnal rhythms. We used data from the Normative Aging Study (Spiro & Bosse, 2001). The 72 men in this study ranged from 67-93 (M =79.29, SD =4.88). Multilevel modeling showed that higher daily stress...
Memory is essential to everyday life. As we age, deficits in memory become apparent. The toll of age-related cognitive impairment can be devastating to families and costly to society. The NMDA receptor is a molecule in the brain that is instrumental in the formation of memories. The receptor is particularly...
Recent experimental and theoretical work has examined the possible genetic causes of senescence. These are reviewed, and four types of factors are found to be responsible for the evolution of senescence and age specific fecundity curves: 1. Age specific mortality schedules, 2.Density dependent factors, 3. Density independent factors, 4. Random...
Oxidative stress is the major driving force behind the aging process and many age-related diseases. However, direct experimental evidence of whether antioxidants, such as ascorbate (AA) and lipoic acid (LA) can slow the progression of aging process and/or reduce risks of developing degenerative disease is largely absent. This suggests a...
The presence of an increased accumulation of intraabdominal fat (IAF) has been linked to dyslipidemia, hyperinsulinemia, and hyperglycemia, which precede the development of type 2 diabetes and coronary artery disease (CAD). It has been shown that IAF begins depostition during childhood. Human studies suggest that regular endurance exercise, that does...
Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...
Overall wood density is a complex trait resulting from the interaction of three components: average earlywood density, average latewood density, and latewood proportion. In order to better understand the genetic control of wood density in juvenile Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco), and to assess the utility of
information on its...
Several behavioral studies have suggested that rarity is critical for enabling irrelevant, salient objects to capture attention. We tested this hypothesis using the event-related potential (ERP) component, N2pc, thought to reflect attentional allocation. A cue display was followed by a target display in which participants identified the letter in a...
