In this thesis, we will study certain generalizations of the classical Shannon Sampling Theorem, which allows for the reconstruction of a pi-band-limited, square-integrable function from its samples on the integers. J. R. Higgins provided a generalization where the integers can be perturbed by less than 1/4, which includes nonuniform and...
Scour is the main cause of bridge failures in the United States. Bridge failures raise a hazard to the safety of the traveling public as well as the massive economic consequences due to the high cost of constructing a new or a replacement bridge. The Oregon Department of Transportation (ODOT)...
Ethnic differences in drug pharmacokinetics are well recognized including that for tacrolimus (TAC) in adult subjects. However, similar knowledge among pediatric populations is missing. Our limited retrospective study compares steady-state pharmacokinetics of TAC in Hispanic versus non-Hispanic children. Serial blood samples were collected and whole blood concentrations of TAC were...
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
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representative findings from two or more independent experiments
HDAC8 repression of BMF
Y Kang et al
2
Cell
