On April 1, 1976, Steve Jobs and Steve Wozniak entered into a partnership agreement to found Apple Computer. In the decade that followed, Apple experienced remarkable growth and success, as Jobs catapulted Apple to the Fortune 500 list of top‐flight companies faster than any other company in history. Under direction...
Leafcutter ants cut trimmings from plants, carry them to their underground nests and cut them into smaller pieces before inoculating them with a fungus that serves as a primary food source for the colony. Cutting is energetically costly, so the amount of cutting is important in understanding foraging energetics. Estimates...
The potential gains that could be realized from
optimizing timber harvesting are significant. To a great
extent it is these initial functions that dictate the
quality of future manufacturing steps. Timber harvesting
systems are defined by the operations they contain and the
equipment that perform them. For any given harvesting...
Circadian clocks coordinate physiological, neurological, and behavioral functions into circa 24 hour rhythms, and the molecular mechanisms underlying circadian clock oscillations are conserved from Drosophila to humans. Clock oscillations and clock-controlled rhythms are known to dampen during aging; additionally, genetic or environmental clock disruption leads to accelerated aging and increased...
Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe cognitive deterioration. While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing the neurotoxic Amyloid-β (Aβ) peptide plays a fundamental role in AD pathogenesis. One of the detrimental...
In the North Pacific Subtropical Gyre (NPSG), the regular occurrence of summer phytoplankton blooms contributes to marine ecosystem productivity and the annual carbon export. The mechanisms underlying the formation, maintenance, and decay of these blooms remain largely unknown; nitrogen fixation, episodic vertical mixing of nutrients, and meso- (<100 km) and...
BACKGROUND: Long non-coding RNAs (lncRNAs) are transcripts that are 200 bp or longer, do not encode proteins,
and potentially play important roles in eukaryotic gene regulation. However, the number, characteristics and
expression inheritance pattern of lncRNAs in maize are still largely unknown.
RESULTS: By exploiting available public EST databases, maize...
An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...
An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...
Full Text:
. Wild, MD, PhD, MPH, ScottM. Grundy, MD, PhD, Martha Daviglus, MD, PhD,
Keith C. Ferdinand, MD
An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...