2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized
for their immunosuppressive activity, which is mediated through an
intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR).
Laboratory animals exposed to TCDD are less resistant to infection and have severely
impaired humoral and cell-mediated immune responses. This dissertation addressed
the hypothesis that...
Chitosan based hemorrhage control dressings provide effective external hemorrhage control while having few side effects. Known residual contaminants present in chitosan formulations include endotoxins and proteins known to stimulate gene expression in the liver. This study investigated gene expression in the liver using rat bio-compatibility models to gain knowledge regarding...
Full Text:
Based Hemostatic Control Patch in Rat Models
By
Andrew J. Colburn
A thesis submitted to
Oregon
Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
Full Text:
By
Andrew Osborn
An Undergraduate Thesis Submitted to
Oregon State University
Chitosan based hemorrhage control dressings provide effective external hemorrhage control while having few side effects. Known residual contaminants present in chitosan formulations include endotoxins and proteins known to stimulate gene expression in the liver. This study investigated gene expression in the liver using rat bio-compatibility models to gain knowledge regarding...
Full Text:
Subcutaneous Chitosan Patch Formulations
Andrew Colburn1, Leslie Dyal, Ph.D.2 and John Mata Ph.D.2
Oregon
In the problem of testing the median using a random sample from a
certain distribution, and if no other parametric family is suggested,
the t-test is known to be the optimal procedure when this distribution
is normal. If the sample appears to be non-normal, one has the choice
either to...
The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
Cascadia’s 1700 earthquake generated a tsunami and widespread subsidence along Pacific Northwest coastline. The tsunami deposited sandy sediments in many Oregon coastal estuaries, such as Alsea Bay. Although the recurrence of subduction-generated megathrust earthquakes and tsunami events in this region are recorded in the stratigraphy, knowledge of the full inland...
Private land-use decisions can have important effects on private and public welfare. Market-based policies to regulate land use have the potential to move the privately-optimal allocation of land closer to what is socially optimal. To implement these policies in the Rocky Mountain states, it is necessary to understand the effects...