Vibrio parahaemolyticus is the leading cause of foodborne illnesses associated with seafood consumption. Consuming raw or undercooked seafood contaminated with V. parahaemolyticus can result in development of acute gastroenteritis with symptoms of nausea, vomiting, abdominal cramping and watery diarrhea within 24 hours of infection. Illness is usually self-limited and lasts...
WLBU2 is an engineered cationic amphiphilic peptide that targets Gram-positive and Gram-negative bacteria, and envelopes endotoxin while avoiding other cell types. The exact mechanism of how WLBU2 targets, binds, and disrupts bacterial cell membranes is still not completely known. Thus, the overall goal of this investigation is to determine the...
Dissolution profiles of two commercial products (Motrine and Rufen®) were analyzed and compared at 8 pH levels, ranging from pH 2.0 to pH 8.0. It was demonstrated, as expected, that the rate and extent of ibuprofen dissolution dissolution was pH dependent. In vitro dissolution characteristics of the ibuprofen solid dispersion...
The fate of antimicrobials entering the aquatic environment is an increasing concern for researchers and regulators, and recent research has focused on antimicrobial contamination from point sources, such as wastewater treatment facility outfalls. The terraccumulation of antimicrobials and mobility in diffuse pollution pathways should not be overlooked as a contributor...
Pharmacokinetic parameters for theophylline and
dyphylline were evaluated in horse cerebrospinal fluid
(csf) and plasma. Pharmacokinetic parameters did not
differ significantly (p > 0.05) at the same dose for
either drug when administered alone or concomitantly.
Theophylline and dyphylline penetrate horse csf to
produce approximately 1/2 the concentrations found in...
This thesis describes a project to produce controlled release ketoprofen beads for capsules, both at Oregon State University and in an industrial scale-up operation, that are bioequivalent to the commercial product Oruvail. A bead formulation was produced by layering drug and binders in water onto nonpareil sugar seeds in a...
Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...