Angiogenesis is an essential process for disease progression in many solid tumors. There are
several major cascade events in the angiogenic process that can be targeted to inhibit new blood
vessel formation in the tumor tissue. The purpose of this work is to evaluate the inhibitory effect
of paclitaxel (PTX)...
PURPOSE: The in vitro inhibitory effect of Docetaxel (DTX) and Everolimus (EVR) alone and together in
poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) nanocarriers on angiogenic
processes and acute toxicity in mice was evaluated.
METHODS: PEG-b-PLA DTX and/or EVR nanocarriers were characterized for size, drug loading, stability,
and drug release. Cell proliferation, tubule...