Although considerable experimental evidence suggests that
endogenous adenosine may function as a modulator of neuronal activity
in the etiology or control of seizures, the neuroanatomical and
neurochemical basis for the anticonvulsant actions of adenosine have
not been well established. A discrete brain region of possible
fundamental importance to epileptogenisis within...
Adenosine is considered to be a neuromodulator or
cotransmitter in the periphery and CNS. This neuromodulatory
action of adenosine may be observed as an anticonvulsant effect.
Dose-response curves for R-phenylisopropyladenosine (PIA),
cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine
(NECA) and S-PIA were generated against
PTZ seizure thresholds in the rat. The rank...
L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in
many organisms, including primates, as an intermediate in lysine degradation. The
pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate
oxidase (L-PO), and appears to be tissue specific to the central nervous system...
Adverse effects of anti-epileptic (AED) medications on bone density have been reported since the 1960s. Phenytoin and carbamazepine, two commonly prescribed AED, are frequently associated with osteomalacia including fractures and reduced bone formation. The mechanism by which AED induces bone loss is not fully explained. We sought to determine the...