This dissertation investigates diverse techniques to support multithreading in modern high performance processors. The mechanisms studied expand the architecture of a high performance superscalar processor to control efficiently the interaction between software-controlled and hardware-controlled multithreading. Additionally, dynamic speculative mechanisms are proposed to exploit thread-level-parallelism (TLP) and instruction-level-parallelism (ILP) on a...
To analyse and project the impact of structural, technological and political changes on food production, the Mexican Government, through the Secretary of Agriculture, Livestock, Rural Development, Fisheries and Food (SAGARPA), is undertaking the analysis of typical production units TPU in the agricultural and livestock sectors, by means of adapting simulation...
During last decade, the excluding efficiency of circle hooks for sea turtle has given positive and successful outcomes in Oaxaca, Mexico. The research seeks: 1) determine if the change of fishing gear provides positive benefits to local small scale longline fishermen, 2) estimate the benefit and cost functions, 3) determine...
Coastal communities in Oregon have experienced dramatic economic and demographic change during the 1980s. Although the timber and fishing sectors are still important, the economies of coastal communities now rely more on non-earned income and tourism. Non-earned income sources, such as transfer payments and investment earnings, account for over forty...
This study presents two new modeling strategies. First, a methodology for
representing the physical process of subsurface storm flow within a TOPMODEL
framework is developed. In using this approach, discharge at quick flow timescales is
simulated, and a fuller depiction of hydrologic activity is brought about. Discharge of
water from...
The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
Congenital hearing loss is a common disorder and over 60 mutations in the sensory hair cell protein, otoferlin, have been linked to pre-lingual deafness. Although otoferlin is essential for hearing, the large size and low solubility of the protein have limited approaches to study its function on a molecular-level. To...
Cell division, arguably the most important event during the life cycle of the eukaryotic cell, is achieved through a complicated yet beautiful machinery. The mitotic spindle — a microtubule-based bipolar structure—is the cellular machinery responsible for the correct segregation of the genetic material, chromosomes. The protein-based nanomachines termed molecular motors...
This dissertation describes studies of isoprenoid biosynthesis in the
phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known
mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Organismal development requires a precisely orchestrated transcriptional program to correctly deploy genetic information into the genome. This process requires sophisticated gene regulatory networks at multiple spatial and temporal levels from early embryonic development to adult physiological conditions. Molecular differences that define cell types are set up during the pattern formation...