The effect of concentration, vehicle and surfactant on the
absorption of benzocaine -³H across the rat's rectal mucosa was
investigated. Blood radioactivity levels were determined after the
application of benzociane -³H containing suppositories and ointments.
A wet oxidation method was used for sample digestion. Since the
radioactivity counted is the...
The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea
(NSC 409962)(BCNU) was investigated in several buffered
aqueous media, in mixed solvent and in nonaqueous solvent
systems, and in the presence of several electrolytes and
nonelectrolytes. The degradation rate constant of BCNU in
these systems was calculated from the parameters of the
linear regression of...
The bioavailability and pharmacokinetics of theophylline
in rabbits were determined following both oral and
intravenous administration of the drug. Serum theophylline
concentrations were determined using high pressure
liquid chromatography. Pharmacokinetic parameters were
determined and verified by computer analysis. The overall
mean Beta disposition constant was 0.089 hr⁻¹ which corresponds
Dyphylline is an analog of theophylline and the latter
is the most popular member of the methylxanthine family in
use for the treatment of asthma. Although dyphylline is
devoid of some problems associated with theophylline, a
reported short half-life has made it's clinical usefulness
limited. To avoid this problem a...
Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
The relative bioavailability and pharmacodynamics
of tolbutamide from two different commercially available
tablet products has been evaluated in healthy subjects
in a single dose cross over study. Products were aged
by exposing tablets to 98% relative humidity for 3 days
at ambient temperature which was found to differentially
Dyphylline is an analogue of theophylline and the
latter is the most popular member of the methyixanthine
family in use for the treatment of asthma. Although
dyphylline is devoid of some problems associated with
theophylline, a reported short half-life for dyphylline
(2.1 hours) has made its clinical usefulness limited. In...