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  • Multi-Technique Characterizations of Natural and Biomimetic Adhesives

    Creator:
    Fowler, James E.
    Abstract:
    There have been many attempts to characterize and mimic natural fluid-based adhesive systems. However, very few of these studies have examined surface or interfacial interactions between adhesive and substrate. Furthermore, until now no study has used a combination of surface analytical and kinematic techniques to determine the precise chemical mechanisms...
    Resource Type:
    Dissertation
    Full Text:
    : _______________________ Joe E. Baio There have been many attempts to characterize and mimic natural fluid

  • Investigating the Hemocompatibility of Blood-Contacting Biomaterials

    Creator:
    Hummel, Madeleine H.
    Abstract:
    Surface-associated thrombosis is a critical concern in medical device development. Current extracorporeal circulation units require systemic anticoagulation to avoid thrombosis, which can cause adverse effects such as thrombocytopenia, hypertriglyceridemia, and hyperkalemia. To address this issue, we combine the technology of polydopamine (PDA) functionalization with slippery liquid infused porous surfaces (SLIPS)....
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: ____________________________________________________ Joe E. Baio Surface

  • Spherical Au Nanoparticle Interaction with Lipid Monolayers Probed with Sum Frequency Generation Spectroscopy

    Creator:
    Faase, Ryan A.
    Abstract:
    Nanoparticles have become more prevalent from their use in sunscreen to antimicrobial agents in socks. In light of these applications, gaining a fundamental understanding of how NPs interact with humans is crucial for their future. Specifically, how cells interact with NPs and what factors drive the modes of cellular uptake....
    Resource Type:
    Masters Thesis
    Full Text:
    : ______________________________________________________ Joe E. Baio Abstract: Nanoparticles have become more prevalent from their use in

  • Probing the Biophysical interactions of Anti-Microbial Peptide WLBU2 Using Model Membrane Systems

    Creator:
    Golbek, Thaddeus W.
    Abstract:
    WLBU2 is an engineered cationic amphiphilic peptide that targets Gram-positive and Gram-negative bacteria, and envelopes endotoxin while avoiding other cell types. The exact mechanism of how WLBU2 targets, binds, and disrupts bacterial cell membranes is still not completely known. Thus, the overall goal of this investigation is to determine the...
    Resource Type:
    Masters Thesis
    Full Text:
    : ______________________________________________________ Joe E. Baio WLBU2 is an engineered cationic amphiphilic peptide that targets Gram-positive and

  • Probing Structure, Selectivity, and Orientation of Biomolecules to Cell Membranes by Sum Frequency Generation

    Creator:
    Golbek, Thaddeus W.
    Abstract:
    Cell membranes act as barriers against unwanted movement of ions and biomolecules and are complex surfaces littered with protein channels, ion channels, cholesterol, and a myriad of different proteins. While this surface is extremely well studied, there is still much we do not know. The work in this dissertation demonstrates...
    Resource Type:
    Dissertation
    Full Text:
    Generation Abstract approved: Joe E. Baio Cell membranes act as barriers against unwanted movement of

  • Self Assembly of GeO₂ Nanoparticles: A Biomimetic Approach

    Creator:
    Gessford, Makayla SueAnn Fu Ting
    Abstract:
    Diatoms are single celled eukaryotic microalgae that self-assemble complex SiO₂ nanostructures by sillafin proteins within their cell wall. There has been increasing interest in mimicking the diatom’s silica self-assembly process for fabricating metal oxide nanoparticles, namely germanium dioxide (GeO₂). GeO₂ has a higher refractive index than silica, enabling it to...
    Resource Type:
    Honors College Thesis
    Full Text:
    Abstract Approved: ________________________________________________ Joe E

  • Chandler Loop Model for the Development of Dynamic Hemocompatibility Assays

    Creator:
    Hasbrook, AnneMarie V.
    Abstract:
    A common issue with extracorporeal medical devices is blood clotting due to bio-incompatibility. Systemic anticoagulants are often prescribed to mitigate the coagulation issues. However, such drugs can lead to further complications, for example hemorrhaging. One solution to improve the hemocompatibility of blood-contacting medical devices are biomaterials, such as slippery liquid...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Joe E. Baio A common issue with extracorporeal medical devices is blood clotting due

  • Surface Characterization of Engineered Biomaterials

    Creator:
    Faase, Ryan A.
    Abstract:
    The work presented in this dissertation highlights the various techniques available to characterize the increasingly complex surfaces of engineered biomaterials. The methods used range from the simple measurement of a contact angle with a smartphone to a complex synchrotron technique like near edge x-ray absorption fine structure (NEXAFS) spectroscopy to...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Joe E. Baio Abstract: The work presented in this dissertation highlights the various

  • Biomimetic synthesis of GeO₂ and TiO₂ utilizing the R5 and poly-l-lysine peptides

    Creator:
    Helman, Talia A., Gessford, Makayla, and Baio, Joe
    Abstract:
    Diatoms, the most common type of algae, are one of the most prevalent organisms in the world. They live in wet ambient environments such as oceans, lakes and rivers and are easily recognizable because of their unique structure. Diatoms are surrounded by a silica cell wall called a frustule. The...
    Resource Type:
    Poster
    Full Text:
    Utilizing the R5 and Poly-L-Lysine Peptides Talia Helman, Makayla Gessford Joe Baio, PhD, School of Chemical

  • Development of a Medicinal Infused Hydrogel Patch for the Treatment of Burns and Diabetic Ulcers

    Creator:
    Griffiths, Abigail E.
    Abstract:
    Metamix is a mixture of botanical compounds that promote healing and prevent infection for burns and diabetic ulcers. In this thesis, metamix was incorporated into 1.75 weight percent gellan gum hydrogels as a drug delivery method for burned skin. The ideal concentration of metamix was 25% by solution volume for...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Joe Baio, Committee Member, representing CBEE