Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
In 2004 the National Toxicology Program published an article describing their intent to pursue toxicology testing and risk assessment practices solely reliant on high throughput in vitro datasets and in silico modeling for dose-response assessments. Support and contributions form regulatory agencies and a significant portion of the life sciences community...
The Euler-MacLaurin sum formula has appeared in the titles
of two quite recent papers whose authors were primarily interested
in certain applications. In this paper a somewhat different approach
to the myriad of formulas for summation, integration, differentiation,
etc. , is based on the simple identity which defines the set...
This thesis is concerned with the detailed derivation
of Sheppard's Correction Formula relating the true to the
raw moments by the use of Euler-MacLaurin formula. Special
moment relationships have been derived using different
special functions, whose application is made to derive correction
formula for the semi-invariants. Special investigation
is carried...