EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Full Text:
GauravBajaj a, Andrew M. Hau a, Peter Hsu a, Philip R. Gafken b,
Michael I Schimerlik c and Jane E
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Full Text:
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Corresponding Author's Institution: Oregon State University
First Author: GauravBajaj, Ph.D.
Order of
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Background: COUP-TF interacting protein 2 [(Ctip2), also known as Bcl11b] is an important regulator of skin homeostasis, and is overexpressed in head and neck cancer. Ctip2(ep-/-) mice, selectively ablated for Ctip2 in epidermal keratinocytes, exhibited impaired terminal differentiation and delayed epidermal permeability barrier (EPB) establishment during development, similar to what...
Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...
The integumentary system is the largest organ system of the body that comprises of skin and its appendages such as hair follicles, sebaceous and sweat glands. Skin is divided into three distinct structural layers: the epidermis, dermis and hypodermis. The epidermis originates from the ectoderm and is composed of four...
Myosins are actin-based molecular motors that may have specialized trafficking and contractile functions in cytoskeletal compartments that lack microtubules. The postsynaptic excitatory synapse is one such specialization, yet little is known about the spatial organization of myosin motor proteins in the mature brain. We used a proteomics approach to determine...
Cutaneous melanoma remains the deadliest form of skin cancer, with a
diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. Previous studies determined that mice selectively lacking the nuclear hormone...