The glaciated coastal mountain watersheds that drain into the Gulf of Alaska (GOA) provide a model laboratory to explore the challenges of hydrological modeling and study the impact of climate and glacier cover change on regional hydrology. The region is data-sparse and contains a complex assemblage of topography and land...
Climate change impacts on extreme water levels (WLs) at two United States Pacific Northwest estuaries are investigated using a multicomponent process-based modeling framework. The integrated impact of climate change on estuarine forcing is considered using a series of sub-models that track changes to oceanic, atmospheric, and hydrologic controls on hydrodynamics....
A comprehensive study of the Gulf of Alaska (GOA) drainage basin was carried out to improve understanding of the coastal freshwater discharge (FWD) and glacier volume loss (GVL). Hydrologic processes during the period 1980–2014 were modeled using a suite of physically based, spatially distributed weather, energy-balance snow/ice melt, soil water...
Around the world, there are numerous examples of collaborative science -industry partnerships, which provide a bottom up approach to trawl gear development. Many have had better success in implementing selective gears as opposed to a top down approach where selective gears are enforced into legislation. On the other hand, such...
The debate over a coastal migration route for the First Americans revolves around two major points: seafaring technology, and a viable landscape and resource base. Three lake cores from Sanak Island in the western Gulf of Alaska yield the first radiocarbon ages from the continental shelf of the Northeast Pacific...
Endoxifen has recently been identified as the predominant active metabolite of tamoxifen and is currently being developed as a novel hormonal therapy for the treatment of endocrine sensitive breast cancer. Based on past studies in breast cancer cells and model systems, endoxifen classically functions as an anti-estrogenic compound. Since estrogen...
An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relation to autoimmune diseases and allergy/asthma as opposed to cancer causation. This is...
The 2014 Working Group on California Earthquake Probabilities (WGCEP 2014) presents time-dependent earthquake probabilities for the third Uniform California Earthquake Rupture Forecast (UCERF3). Building on the UCERF3 time-independent model published previously, renewal models are utilized to represent elastic-rebound-implied probabilities. A new methodology has been developed that solves applicability issues in...
The 2014 Working Group on California Earthquake Probabilities
(WGCEP14) present the time-independent component of the Uniform California
Earthquake Rupture Forecast, Version 3 (UCERF3), which provides authoritative
estimates of the magnitude, location, and time-averaged frequency of potentially
damaging earthquakes in California. The primary achievements have been to relax
fault segmentation and...
Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of individual agents at singular endpoints. As such, they have incompletely addressed both the pro-carcinogenic contributions of environmentally...