We present molybdenum isotope and concentration data from 14 sites in the eastern Pacific from the
central California to the Peru margin. The environments studied have been chosen to represent a broad
range in oxidation-reduction (redox) potential, which provide a framework for the behavior of this redox-sensitive
element. Manganese-rich hemipelagic...
Diatom remains indicate the oceanic Ge/Si ratio (μmol/mol) has varied temporally, ranging from Miocene values of 0.9 to Last Glacial Maximum (LGM) values of 0.55, with the present value of 0.69. These ratios lie between those for the primary sources for these elements: continental weathering (Ge/Si = 0.5) and hydrothermal...
Benthic incubation chambers have been deployed in a variety of geochemical environments that provide a comprehensive geochemical framework from which to address issues related to Ba geochemistry and the use of Ba as a paleoproxy. First order budgets for barium show that in the equatorial Pacific, present rates of Ba...
Objective: To examine the pricing trajectories in the United States of disease-modifying therapies (DMT) for multiple sclerosis (MS) over the last 20 years and assess the influences on rising prices.
Methods: We estimated the trend in annual drug costs for 9 DMTs using published drug pricing data from 1993 to...
Acid deposition and repeated biomass harvest have decreased
soil calcium (Ca) availability in many temperate forests worldwide, yet
existing methods for assessing available soil Ca do not fully characterize
soil Ca forms. To account for discrepancies in ecosystem Ca budgets, it
has been hypothesized that the highly insoluble biomineral Ca...
Graphical methods for displaying uncertainty are often the most concise and informative way to communicate abstract concepts. Presentation methods currently in use for the display and interpretation of scientific uncertainty are reviewed. Numerous subjective and objective uncertainty display methods are presented, including qualitative assessments, node and arrow diagrams, standard statistical...
OBJECTIVE: To evaluate the effectiveness of a 3-month treadmill desk intervention in eliciting changes in physical activity and sedentary behavior among overweight/obese office workers. METHODS: A randomized controlled trial was conducted among overweight/obese office workers (n=41; mean age = 40.1 ± 10.1 years) at a private workplace. Participants were randomly...
CONTEXT: In older adults with multiple conditions, medications may not impart the same benefits seen in patients who are younger, or without multi-morbidity. Furthermore, medications given for one condition may adversely affect other outcomes. Beta-blocker (β-Blocker) use with coexisting cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD) is such...
A radioactive particulate release experiment to produce a near-field ground deposition representative of small-scale venting from an underground nuclear test was conducted to gather data in support of treaty capability development activities. For this experiment, aCO₂‐driven “air cannon” was used to inject ¹⁴⁰La, a radioisotope of lanthanum with 1.7‐d half-life...
Background—The effect of intensive blood pressure (BP) lowering on kidney function among individuals with established cerebrovascular disease and preserved estimated glomerular filtration rate (eGFR) is not established.
Methods and Results—Among 2610 participants randomized to a lower (<130 mm Hg) versus higher (130–149 mm Hg) systolic BP target with repeated measures...