The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of
senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted
melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and
ribonucleotide...
Continental shelf sediments are sinks for dissolved oxygen and sources of many major and minor nutrients required for oceanic surface primary production, resulting in a strong coupling between benthic and pelagic biogeochemical cycling. However, the influence and spatiotemporal variability of benthic remineralization on bottom-water chemistry and the supply of nutrients...
Previous projects in the Gulf of Lion have investigated the path of terrigenous material
in the Rhone deltaic system, the continental shelf and the nearby canyon heads. This
study focuses on the slope region of the Gulf of Lion to further describe particulate
exchanges with ocean’s interior through submarine canyons....
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in
carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive
agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor
suppressor genes silenced...
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Epithelial Cells and Prostate Cancer Cells
Carmen P. Wong1,2, Anna Hsu1,2, Alex Buchanan1, Zoraya Palomera
Two major types of glycerol dialkyl glycerol tetraethers (GDGTs) are commonly
used in paleoecological and paleoclimatological reconstructions: isoprenoidal and
branched GDGTs. In aquatic environments, it was originally assumed that isoprenoidal
GDGTs, especially crenarchaeol, derive mainly from aquatic Thaumarchaeota, whilst
branched GDGTs are an allochthonous input derived from soil Bacteria. Recently,...
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, Fredrick G. Prahlf, Sergio Rossia, Gemma Ruedaa, Anna 5
Sanson-Barreraa, Antoni Rosell-Meléa,g 6
aICTA
The term, spirituality, as used in this study, refers
to that part of our lives that has the deepest meaning,
that which nurtures each of us and moves us toward wholeness.
It is the basis for which we live out our lives,
following our own truths with honesty and commitment....
We present field data and data from the literature to highlight the effects of low-tide rainfall on particulate organic carbon (POC) redistribution in intertidal landscapes. The POC exchanges reported from disparate but related studies were standardized to a storm-induced exchange rate (gPOC m⁻² mmRain⁻¹) and compared. Results show that these...
Severe wildfires are increasing in the western United States, impacting vegetation structure, and in turn, forest regeneration conditions. These wildfires are also raising a substantial amount of scientific and management concern regarding the resilience of forested ecosystems, or the ability of the ecosystem to return to a pre-fire condition. This...
Although deep reinforcement learning agents have produced impressive results in many domains, their decision making is difficult to explain to humans. To address this problem, past work has mainly focused on explaining why an action was chosen in a given state. A different type of explanation that is useful is...