Index Catalog // ScholarsArchive@OSU

Studies Toward the Synthesis of Natural Product Scaffolds

Creator:: Lusk, Jason S.
Abstract:: Part 1: A Diels-Alder Approach to the Synthesis of Novel Analogues of the Natural Product Siamenol Due to the prevalence of biaryl motifs in natural product synthesis, the Carter research group has been exploring the utility of a Diels-Alder approach to biaryl synthesis. The Diels-Alder approach involves a [4+2] cycloaddition...
Resource Type:: Honors College Thesis
Full Text:: ______________________________________________________________________ Paul Blakemore, Committee Member, representing Synthetic Organic Chemistry

Part I: Total Syntheses of Mandelalide A and Isomandelalide A. Part II: Role of π-Stacking on Sharpless Dihydroxylation of cis-Enynes: Synthetic Studies Toward All Carbon Macrocyclic Mandelalide B

Creator:: Ghosh, Ankan
Abstract:: Part I of this dissertation includes the chronological synthetic background of mandelalide A as well as the synthesis of the C1-C14 glycosylated southern subunit of mandelalide. A key aspect of the synthesis includes a novel silver-catalyzed cyclization (AgCC) of a propargylic benzoate to construct the substituted cis-pyran ring system present...
Resource Type:: Dissertation
Full Text:: extend my thankfulness to Prof. Paul R. Blakemore and Prof. Sandra Loesgen with whom I took most of the

Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects

Creator:: Heppe, Kenan G.
Abstract:: F1FO-ATP synthase targeting antimicrobials apoptolidin 1 (A1), (+)-erythromefloquine, and oligomycin were tested in vitro for synergistic minimum inhibitory concentrations against Staphylococcus aureus. Synergy was strictly defined as inhibition by at most 25% the MIC of each participating drug. Ampicillin, with an MIC of 0.8 ug/mL, served as a negative control....
Resource Type:: Honors College Thesis
Full Text:: the towel. Dr. Paul Blakemore, no matter how busy, always made time to answer my questions. His

Exploring the Synthesis of 4-Deoxygadusol

Creator:: Jujjuri, Anantha Poojitha
Abstract:: Sunscreen products are used worldwide to protect the skin from ultraviolet radiation. However, some of the ingredients used in sunscreen products are fatal to coral reefs especially in areas where tourism is a large part of the economy. In this study, we explored a synthetic route to produce 4-deoxygadusol, which...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Paul Blakemore, Committee Member, representing Chemistry

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Creator:: Kim, GilSoo
Abstract:: The first part of this manuscript is about the total synthesis of the aspidosperma alkaloids leuconoxine, melodinine E and mersicarpine. Our synthetic strategy used a radical translocation-conjugate addition cascade to construct the core of the natural product. Specifically, a vinyl radical was generated from the homolysis of the C–I bond...
Resource Type:: Dissertation

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:: Snyder, Kevin M.
Abstract:: In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
Resource Type:: Masters Thesis
Full Text:: Synthesis Abstract approved: ______________________________________________________ Paul Ha

Racemic and Enantioselective Synthesis of Cavicularin

Creator:: Zhao, Peng
Abstract:: This dissertation describes the racemic and enantioselective synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been an attractive synthetic target due to its intriguing structure: the macrocyclic core imparts sufficient strain on the system to force one benzene rings to adopt a boat-shaped conformation, out...
Resource Type:: Dissertation

Progress Towards the Total Synthesis of Bazzanin K

Creator:: Salvo, Patrick
Abstract:: Molecular chirality plays a critical role in chemistry, biology, and medicine. To study and better understand conformational chirality, it is necessary to obtain structurally interesting molecules that exhibit this form of chirality. Our lab utilizes total synthesis and methodological development to obtain conformationally chiral natural products of interest. We believe...
Resource Type:: Masters Thesis

Terahertz transmission & spectroscopy of vertically grown multi-walled carbon nanotube forests

Creator:: Maizy, Louis
Abstract:: In this thesis, I present studies in the field of terahertz [THz] spectroscopy. It covers both the generation and detection of ultra-fast broadband THz pulses, as well as the transmission properties of vertically grown multi-walled carbon nanotube forests [MWCNTs]. We have found that these vertically grown MWCNTs respond strongly to...
Resource Type:: Masters Thesis
Full Text:: . Finally, to my prede- cessors Andy Jameson, Joe Tomaino, and Michael Paul, for sharing their knowledge

Improvements in synthesis and response techniques of ion-selective sensors

Creator:: Pylypiuk, Nataliia
Abstract:: Two improvements to the established procedures for synthesis and response detection of ion-selective optical sensors (optodes) were introduced. The first improvement addresses the drawback of organic dye (optode-localized chromoionophore) photobleaching. This positively impacts fluorescence response and allows for (1) direct measurement of hydrogen ion activity upon binding with the dye,...
Resource Type:: Masters Thesis
Full Text:: commitment of my graduate committee members: Kim Anderson, Paul Blakemore and Christopher Beaudry

ScholarsArchive@OSU

Studies Toward the Synthesis of Natural Product Scaffolds

Part I: Total Syntheses of Mandelalide A and Isomandelalide A. Part II: Role of π-Stacking on Sharpless Dihydroxylation of cis-Enynes: Synthetic Studies Toward All Carbon Macrocyclic Mandelalide B

Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects

Exploring the Synthesis of 4-Deoxygadusol

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Racemic and Enantioselective Synthesis of Cavicularin

Progress Towards the Total Synthesis of Bazzanin K

Terahertz transmission & spectroscopy of vertically grown multi-walled carbon nanotube forests

Improvements in synthesis and response techniques of ion-selective sensors

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