Doxorubicin is a widely used cancer therapeutic, but its effectiveness is limited by cardiotoxic side effects. Evidence suggests cardiotoxicity is due not to doxorubicin, but rather its metabolite, doxorubicinol. Identification of the enzymes responsible for doxorubicinol formation is important in developing strategies to prevent cardiotoxicity. In this study, the contributions...
Dispersal is integral to our understanding of the life history and population biology of many vertebrates, but difficulties in detecting long distance movements have complicated its study. Moreover, studies of factors affecting dispersal are often unable to determine the relative contributions of variables such as nesting success, mate fidelity, and...
Cyclopropenoid fatty acids (CPFA) are unique compounds that
contain a highly strained and reactive cyclopropene ring structure.
These compounds have been shown to cause a number of toxic effects
in a variety of animals. Rainbow trout (Salmo gairdneri) have
proven to be particularly sensitive to CPFA. Studies have revealed
that...
Pseudomonas butanovora, Mycobacterium vaccae, and Nocardioides sp. CF8 utilize distinctly different butane monooxygenases (BMOs) to initiate degradation of recalcitrant chlorinated ethenes (CEs) that pollute aquifers and soils. BMO-dependent degradation of CEs such as trichloroethylene (TCE) can lead to cellular toxicities. The type and severity of TCE transformation-dependent damage can have...
A heat stable protease was identified as the cause of textural degradation in cooked arrowtooth flounder (Atheresthes stomias) muscle. Maximum proteolytic activity in the fish muscle was observed between 55°C and 60°C and myosin heavy chain appeared to be the primary substrate for the enzyme. Degradation of this myofibrillar protein...
The Steel Plate Shear Wall (SPSW) system, is an innovative seismic lateral force resistant system, which has experienced increased use over the last three decades. The SPSW system is composed of boundary elements which anchor web plates that develop diagonal tension fields. A number of SPSW buildings have been built...
Meeting the energy demands of the future is one of the most important challenges facing the engineering community today. An example of this problem is transportation fuels. Most of the current transportation fuels are composed of petroleum hydrocarbons. Finding a viable alternative is important given the potential scarcity of these...
The majority of our modern understanding of bacterial pathogenesis is based on the strategy that involves screening bacterial genomes for the presence of the genes encoding pathogenic factors, and analysis of these genes via forward and reverse genetics. Chlamydiae represent a unique group of pathogenic bacteria in which it is...
The formation of cytosine hydroperoxide was detected in
aqueous cytosine solutions irradiated with Co-60 γ-rays at pH 2.
The nucleotide of cytosine, cytidylic acid, forms a hydroperoxide
which was detected in neutral solution. The stability of the hydroperoxides of cytosine, thymine, and their nucleotides was found to
be a function...
The prevalence of childhood illness requiring hospitalization establishes the need for implementation of an applied intervention to decrease levels of hospitalization-induced anxiety in pediatric patients. In addition to anxiety, levels of perceived trauma have also been linked to pre-operative pediatric patients. Child-Centered Play Therapy (CCPT) within the medical setting has...
:
___________________________________________________________________
Daniel Stroud
The prevalence of childhood illness requiring hospitalization establishes