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  • Second Derivative Excitation Emission Resolution (SEC DEER) Spectroscopy

    Creator:
    Rosene, Benjamin L.
    Abstract:
    Fluorescence spectroscopy is a powerful analytical technique due to bright signals that provide excellent measurement sensitivity. Many colors of fluorescent dyes are available to match the detection ranges of different equipments. Dyes can be chemically modified to bind to many different target analytes with high specificity1. Alternatively, sensors can be...
    Resource Type:
    Honors College Thesis
    Full Text:
    : _____________________________________________________________________ Sean M. Burrows, Mentor, representing Department of Chemistry

  • Thermodynamic Design Principles for Double-Strand Displacement microRNA Biosensors

    Creator:
    Smith, Natasha M.
    Abstract:
    In recent years, microRNA’s (miRNA’s) have emerged as important in regulating gene expression. Fluctuations in their levels are associated with the up or down-regulation of tumor-suppressor genes and oncogenes. Thus, the ability to visualize changes in miRNA is an important step in understanding cancer emergence and development. The Burrows group...
    Resource Type:
    Honors College Thesis
    Full Text:
    : _____________________________________________________ Sean M. Burrows In recent years, microRNA’s (miRNA’s) have

  • CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

    Creator:
    Almlie, C. Kyle
    Abstract:
    Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
    Resource Type:
    Dissertation
    Full Text:
    approved: ______________________________________________________ Sean M. Burrows Fluorescence has

  • Improving Bioanalytical Methods of miRNA Analysis and its Applications to Breast Cancer

    Creator:
    Tran, Victoria
    Abstract:
    Micro-ribonucleic acids (miRNA) are becoming an increasingly popular topic of research in hopes of discovering newfound biomarkers and/or therapies for numerous types of cancers and diseases. MiRNA are a type of biomolecule contributing to the progression of multiple cancers and diseases, and such biomolecules are called biomarkers. Current RNA-based biosensors...
    Resource Type:
    Honors College Thesis
    Full Text:
    : ________________________________________________________________________ Sean M. Burrows Micro-ribonucleic acids (miRNA) are becoming an increasingly popular

  • Gold Nanostars: Spectroscopic and Physical Properties

    Creator:
    Zhou, Lixia
    Abstract:
    Tethering fluorophores on metal nanoparticles for metal enhanced fluorescence (MEF) has attracted a lot of attention from scientists interested in fluorescence based approaches. MEF has many benefits in fluorescence related techniques, because the analytical signal increases and enables potentially lower detection limits or better sensitivity. Many types of nanoparticles have...
    Resource Type:
    Dissertation
    Full Text:
    Sean M. Burrows Tethering fluorophores on metal nanoparticles for metal enhanced

  • Synthesis and SERS : Reproducible Nanostar Plasmons and a Study of Optical Enhancement

    Creator:
    Ramsey, Jacob D.
    Abstract:
    Gold nanostars are a relative newcomer to the nanoparticle scene, and their unique properties make them very desirable for spectroscopic applications. These nanoparticles, with their sharp tips, create electric field enhancements that interact with light in an advantageous way. This Thesis outlines our in-depth study of gold nanostar synthesis, the...
    Resource Type:
    Honors College Thesis
    Full Text:
    : ______________________________________________________ Sean M. Burrows Gold nanostars are a relative newcomer to the nanoparticle scene, and

  • Innovative Bioanalytical Tools & Methods for Combinatorial Non-Coding RNA Analysis

    Creator:
    Zhang, Lulu
    Abstract:
    Recently researchers have discovered that groups of small non-coding RNAs (ncRNAs) play regulatory roles in gene expression and participate in various biological processes. For example, pathogenesis of many diseases, cell cycle regulation, and signaling pathways. Intracellular and live cell imaging of small ncRNA groups will reveal their relative expression levels...
    Resource Type:
    Dissertation
    Full Text:
    Sean M. Burrows Recently researchers have discovered that groups of small non-coding RNAs

  • Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

    Creator:
    Larkey, Nicholas E.
    Abstract:
    One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: ______________________________________________________ Sean M. Burrows

  • Electrochemical Micro-sensors for Probing Bacterial Metabolic Behavior with Scanning Electrochemical Microscopy

    Creator:
    Jayathilake, Nadeeshani M.
    Abstract:
    Dental plaque is one of the well-characterized biofilms in the human body. Oral bacterial species play vital roles in maintaining healthy bacterial homeostasis as well as causing oral infections. Many of the oral diseases are caused by opportunistic pathogens, and therefore, the bacterial metabolic activities become important in dictating their...
    Resource Type:
    Dissertation
    Full Text:
    . Remcho, Dr. David Ji, Dr. Sean Burrows, Dr. Wei Kong and Dr. Weihong Qiu for your valuable advice and

  • Investigating Low-Frequency Vibrations in Condensed Matter Using Time-Resolved Third-Harmonic Generation Spectroscopy

    Creator:
    Wang, Liang
    Abstract:
    In this thesis, I present a new method we developed to study low frequency (< 700 cm⁻¹) vibrational dynamics: Time-resolved third-harmonic generation (TRTHG) spectroscopy. Among a variety of vibrational spectroscopy techniques, TRTHG differentiates itself with robustness, versatility, and simplicity. In TRTHG experiment, that involves only two ultrashort laser pulses, the...
    Resource Type:
    Masters Thesis
    Full Text:
    other members in graduate committee, including Dr. Wei Kong (Prof. of chemistry), Dr. Sean Burrows