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  • Intestinal hyperplasia and neoplasms in zebrafish (Danio rerio)

    Creator:
    Paquette, Colleen Elizabeth
    Abstract:
    Zebrafish (Danio rerio) have become an increasingly important model organism for cancer research. There are several cancer models in which neoplasms are induced chemically or genetically. However, spontaneous (unknown etiology) neoplasms are rather common in zebrafish, particularly in older fish. For over a decade, spontaneous intestinal neoplasia and preneoplastic intestinal...
    Resource Type:
    Masters Thesis
    Full Text:
    …………………………………………………………………5 Cancer in the Mammalian Gastrointestinal Tract.………………………...1 Zebrafish as a Cancer Model

  • The Effect of Cytokines on Wild-type and Fanconi Mouse Embryonic Fibroblasts.

    Creator:
    Wagner, Katherine L.
    Abstract:
    Fanconi's Anemia (FA) is an autosomal recessive chromosomal instability disorder. The symptoms include congenital abnormalities, defective hematopoiesis (formation of cells of the blood), and high risk of developing acute myeloid leukemia and solid tumors. Fanconi researchers have long been puzzled by how Fanconi Anemia (FA) cells, which are known to...
    Resource Type:
    Honors College Thesis

  • Growth pathways in feline oral squamous cell carcinoma

    Creator:
    Harris, Krystal, L.
    Abstract:
    Background Bcl11b, previously CTIP2, is a zinc finger nuclear transcription factor involved in the development of keratinocytes, teeth, T lymphocytes, and nervous tissue. Expression of Bcl11b has been reported in human head and neck squamous cell carcinoma (HNSCC) and increased expression correlates with poorly differentiated tumors. This study aimed to...
    Resource Type:
    Masters Thesis
    Full Text:
    animal model (Tannehill-Gregg et al 2006). FOSCC cell lines Our study utilized three FOSCC cell

  • Canine LH Receptors Expression in Non-neoplastic and Neoplastic Tissues

    Creator:
    Zwida, Khawla
    Abstract:
    Throughout most of the developed world, surgical sterilization via gonadectomy has become a common tool for combating the overpopulation of unwanted dogs as well as to eliminate the risk of reproductive diseases in pet dogs. In the dog as in other normal adult mammal, the hypothalamus secretes gonadotropin-releasing hormone (GnRH),...
    Resource Type:
    Masters Thesis
    Full Text:
    THE THESIS OF Khawla Zwida for the degree of Master of Science in Animal Sciences presented on

  • Some mathematical models in ecology

    Creator:
    Engstrom-Heg, Verna Louise
    Resource Type:
    Masters Thesis
    Full Text:
    . . . . . . . . . . . . . . 11 The Single-Species Model . . . . . . . . . . il A Model for the Study of Two Species . . . . A

  • Mathematical modeling and the control of immune processes with application to cancer

    Creator:
    Lee, Kwon Soon
    Abstract:
    A foundation for the control of tumors is presented, based upon the formulation of a realistic, knowledge-based mathematical model of the interaction between tumor cells and the immune system. The parametric control variables relevant to the latest experimental data, e.g., the sigmoidal dose-response relationship and Michaelis-Menten dynamics, are also considered....
    Resource Type:
    Dissertation
    Full Text:
    - struction of a mathematical model. 2.1.1 Tumor Antigens Cancer is a term used to encompass a wide range of

  • Evaluation of zebrafish (Brachydanio rerio) as a model for carcinogenesis

    Creator:
    Tsai, Hsi-Wen
    Abstract:
    Zebrafish (Brachydanio rerio) are small, freshwater teleost fishes in the family Cyprinidae, the true minnows. They are native to the tropical latitudes of India, but have become widespread through their use as aquarium fish and as models for several branches of biological research. Their ease of rearing, short generation time,...
    Resource Type:
    Dissertation
    Full Text:
    could be of great use in cancer research. The embryos are transparent and offer a superb model for

  • Ras oncogenes and p53 suppressor genes in fish carcinogenesis models

    Creator:
    Cheng, Ronshan
    Abstract:
    A digoxigenin-labeled nonradioactive detection system was used to screen a zebrafish cDNA library for p53-like and ras-like genes. One clone was isolated and identified as an incomplete p53-like gene. The insert size of this clone is 1777 bp, which encodes part of evolutionarily conserved region II and all of regions...
    Resource Type:
    Dissertation
    Full Text:
    human and animal models. Chapter 2 is a literature review of the biological and biochemical functions

  • Determination of flavin-containing monooxygenase mRNA levels in mouse lung and liver

    Creator:
    Lo, Pachida C.
    Abstract:
    We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucidate the role of active human FMO isoform 2 (FMO2.1) in xenobiotic metabolism and toxicity. Since FMO2 is primarily expressed in lung this will provide information on how 27% of African-Americans and 5% of Hispanics...
    Resource Type:
    Honors College Thesis

  • Range of motion of beetle body as a function of foot positions

    Creator:
    Foo, Chee Kit
    Abstract:
    This thesis presents a method for determining range of body motion for a walking machine with feet fixed on the ground. The darkling beetle was selected as the sample subject in this study. A closed form inverse kinematic solution is used to determine if a point in space is within...
    Resource Type:
    Masters Thesis
    Full Text:
    , selecting a sample subject animal with locomotion confined to walking or running would be an advantage