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  • Factors contributing to the formation of CC-->TT tandem mutations

    Creator:
    Skinner, Amy M.
    Abstract:
    The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
    Resource Type:
    Dissertation
    Full Text:
    Toxicology Head of the Department of Environmental and Molecular Toxicology

  • Phylogenetic Estimation and Ancestral State Reconstruction of Rubus (Rosaceae) using Target Capture Sequencing

    Creator:
    Carter, Katherine A.
    Abstract:
    Hybridization, polyploidy, and apomixis have made phylogenetic estimation in Rubus challenging. I used target capture to sequence approximately 1000 low copy nuclear loci and the chloroplast genome for 94 accessions representing the genus Rubus and distributed worldwide. Species phylogenies were estimated using two coalescent based methods, ASTRAL-II and SVDQuartets, and...
    Resource Type:
    Masters Thesis
    Full Text:
    ....................................................................................................13 Molecular Markers for Phylogenetic Analyses in Rubus

  • Investigating tumor suppression in triploid trout

    Creator:
    Ford, Bryan L.
    Abstract:
    Previous work (Thorgaard, G. H. et al., Aquatic Toxicology 46:121-126, 1999) showed triploid rainbow trout (0. mykiss) given embryonic carcinogen bath exposures had significant reduction of induced tumors relative to diploids. In the present study, trout were made triploid by thermal shock after fertilization. At age of 5 months they...
    Resource Type:
    Dissertation

  • Characterization of Pacific whiting proteinase P-II and partial cloning of cathepsins L and K cDNA from rainbow trout liver

    Creator:
    Nickel, Xianbin F.
    Abstract:
    Proteinase P-II purified from parasitized Pacific whiting muscle was previously identified to be one form of cathepsin L. It appeared to be present in three isozymatic forms on non-denaturing PAGE gel stained for activity. Its autolytic degradation was observed on SDS-PAGE gel under its optimum condition, 55°C and pH 5.5,...
    Resource Type:
    Masters Thesis
    Full Text:
    Homology and Molecular Structure of Cysteine Proteinases 7 Processing of Procathepsins 8 Polymerase

  • Phylogenetic Studies in Tenebrionidae (Coleoptera) and Related Families

    Creator:
    Kanda, Kojun
    Abstract:
    In this dissertation, I present the results from three studies: (1) a phylogeny of Tenebrionoidea (Coleoptera) inferred from a seven-gene dataset derived from PCR and Sanger sequencing; (2) a phylogeny of Tenebrionidae, the largest family in Tenebrionoidea, inferred from a four-gene dataset also derived from PCR and Sanger sequencing; (3)...
    Resource Type:
    Dissertation
    Full Text:
     ...............................................................................................  3     Chapter  2:  Molecular  phylogeny  of  Tenebrionoidea  (Coleoptera

  • Advances in molecular systematics of clavicipitaceous fungi (Sordariomycetes: Hypocreales)

    Creator:
    Kepler, Ryan M.
    Abstract:
    Historical concepts of Clavicipitaceae have included a broad range of species that display diverse morphologies, ecological modes and host associations. When subjected to multigene phylogenetic investigation of evolutionary history, the family was found to be polyphyletic, largely driven by diversity in the genus Cordyceps, previously containing over 400 taxa. The...
    Resource Type:
    Dissertation
    Full Text:
    presented on November 24, 2010. Title: Advances in Molecular Systematics of Clavicipitaceous Fungi

  • DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

    Creator:
    Smith-Roe, Stephanie L.
    Abstract:
    The DNA mismatch repair (MMR) pathway maintains genomic stability and reduces cancer risk (colorectal and other internal cancers) by correcting polymerase errors and activating cell cycle checkpoints and apoptosis in response to DNA damage. Few studies have examined the influence of commonly encountered environmental mutagens/carcinogens on the etiology of MMR-deficient...
    Resource Type:
    Dissertation
    Full Text:
    , members of the Buermeyer and Hays labs, and members of the Environmental and Molecular Toxicology

  • From fossils to phylogenies

    Creator:
    Goodwin, Baylee N., Besser, August D., and Ramsey, Stephen A.
    Abstract:
    The research question address in this study is, “To what extent will the use of hands-on activities for introducing concepts in bioinformatics promote student engagement in after-school STEM club settings?” It is hypothesized that high school students' engagement in hands-on bioinformatics activities promotes their awareness of, and interest in, STEM...
    Resource Type:
    Learning Object and Presentation
    Full Text:
    ” ➢ “Molecular Phylogenetics of Mastodon and Tyrannosaurus Rex” ➢ “Biomolecular Characterization and Protein

  • Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

    Creator:
    Codding, Sara Jone
    Abstract:
    The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
    Resource Type:
    Dissertation
    Full Text:
    and structure on a molecular level. To do this successfully, a variety of biochemical and

  • New Insights into the Molecular Mechanism of Clostridium perfringens Spore Germination

    Creator:
    Banawas, Saeed S.
    Abstract:
    C. perfringens is a spore-forming, gram-positive, anaerobic pathogenic bacterium capable of causing a wide variety of diseases in both humans and animals. However, the two most common illnesses in humans are C. perfringens type A food poisoning (FP) and non-food-borne (NFB) gastrointestinal (GI) illnesses. Interestingly, these two major diseases are...
    Resource Type:
    Dissertation
    Full Text:
    Microbiology presented on May 9, 2016 Title: New Insights into the Molecular Mechanism of Clostridium