Index Catalog // ScholarsArchive@OSU

Exploring reproductive signaling using nonconventional aquatic models : Aging and reproductive function in killifish and sea anemones

Creator:: Ferguson, Lindsey G.
Abstract:: Aquatic animals possess surprising similarities to humans in reproductive signaling that are simplified or elaborated for life underwater, making them useful for studying reproductive control. In this thesis, killifish and sea anemones are used as models for reproductive function and aging. The aging model Nothobranchius (killifish) was used to investigate...
Resource Type:: Honors College Thesis
Full Text:: Patrick Chappell Aquatic animals possess surprising similarities to humans in reproductive signaling

Generation of Kisspeptin Cell Lines to Investigate the Sex Steroid-Mediated Initiation of Puberty

Creator:: Jacobs, Dakota C.
Abstract:: Mammalian female reproduction requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from neurons in the preoptic area (POA) of the hypothalamus, initiated by elevated estradiol (E₂). Rising E₂ activates a subset ofsexually dimorphic Kisspeptin neurons in the female, located in the anteroventralperiventricular nuclei (AVPV). Conversely, E₂ negative feedback is mediated by...
Resource Type:: Presentation and Undergraduate Thesis

Loss of rhythmic circadian clock gene expression is associated with decreases in estrogen receptor expression in canine mammary cancer

Creator:: Hughes, Kelly L.
Abstract:: The endogenous circadian clock is an intracellular transcriptional feedback loop timing daily patterns of multiple biological rhythms within a 24-hour period. Disturbance in various rhythms leads to alteration of normal biological processes including cellular proliferation and tumor suppression. Endogenous circadian clock rhythms have been found to be disrupted in breast...
Resource Type:: Masters Thesis
Full Text:: : ______________________________________________________ Patrick E. Chappell Abstract: The endogenous circadian clock is an intracellular

Effects of Perfluorinated Compounds on GnRH Gene Expression in vitro

Creator:: Bathke, Rebecca E.
Abstract:: Perfluorinated chemicals have been widely used in industry for their superior surfactant qualities. Because of their widespread usage and resistance to photolytic and biodegradation mechanisms, as well as their ability to undergo long-range atmospheric transport, these compounds have become ubiquitous in the world-wide water supplies. Of particular interest are perfluorooctanoic...
Resource Type:: Undergraduate Thesis and Presentation

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

Creator:: Starman, Alia
Abstract:: Multicellular coordination in response to environmental stimuli is essential in biology, and this coordination is often achieved by a division of labor to establish leaders and followers in a cell population. This is called emergent leadership, but how a cell adopts its role and effectively exchanges information with peers is...
Resource Type:: Honors College Thesis
Full Text:: approved:_____________________________________________________ Patrick Chappell Multicellular

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Creator:: Ewton, Jessica
Abstract:: Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...
Resource Type:: Honors College Thesis
Full Text:: Hormone Expressing Neurons. Abstract approved: a Patrick Chappell Gonadotropin-releasing hormone (GnRH

Circadian Clock Disruption via Exposure to Extended Light at Night (LAN) Alters Epigenetic Expression of CKI Genes in the Murine Mammary Gland

Creator:: Rogers, Zackry L.
Abstract:: Breast cancer is a leading cause of cancer deaths among women, with an estimated 12.4% of American women diagnosed with this tumor type. Evidence suggests that exogenous disruptors can exert epigenetic changes leading to aberrant gene expression, shifting the cellular balance toward oncogenesis. While chemical pollutant exposure is well-studied, light...
Resource Type:: Honors College Thesis
Full Text:: Mammary Gland. Abstract approved:_____________________________________________________ Patrick Chappell

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

Creator:: Rayzman, Noa
Abstract:: Estradiol (E2) plays a role in positive and negative feedback mechanisms of the hypothalamic-pituitary-gonadal (HPG) axis in female mammals. These mechanisms are regulated by two different populations of kisspeptin (KP)-producing neurons: anteroventral periventricular (AVPV) neurons, which are stimulated by E2, and arcuate (arc) neurons, which are inhibited by E2. AVPV...
Resource Type:: Honors College Thesis
Full Text:: approved:_____________________________________________________ Patrick Chappell Estradiol (E2) plays a

The Analysis of Kisspeptin Neuronal Exosomes and their Effects in the Periphery at the Level of the Bone

Creator:: James, Teagan
Abstract:: Estrogen (E2) is essential for multiple physiological effects in females, ensuring maximum reproductive fitness and maintaining skeletal homeostasis. E2 has been shown to stimulate cancellous bone formation via activation of estrogen receptor alpha (ERα), an effect widely accepted to be mediated directly at bone. A recent landmark study by Herber...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Patrick Chappell Estrogen (E2) is essential for multiple physiological effects in females

Circadian Dysregulation is Associated with Alterations in Tumor Suppressor Activity in Murine Mammary Tissue

Creator:: Aponso, Hiruni M.
Abstract:: Breast cancer is the second most common cancer among women in the US, however, only a small fraction of cases are attributable to heritable genetic mutations; the bulk arises from various behavioral and environmental factors. Loss of functional p53 is observed in over 50% of cases, and its activity relies...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Patrick Chappell Breast cancer is the second most common cancer among women in the US

ScholarsArchive@OSU

Exploring reproductive signaling using nonconventional aquatic models : Aging and reproductive function in killifish and sea anemones

Generation of Kisspeptin Cell Lines to Investigate the Sex Steroid-Mediated Initiation of Puberty

Loss of rhythmic circadian clock gene expression is associated with decreases in estrogen receptor expression in canine mammary cancer

Effects of Perfluorinated Compounds on GnRH Gene Expression in vitro

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Circadian Clock Disruption via Exposure to Extended Light at Night (LAN) Alters Epigenetic Expression of CKI Genes in the Murine Mammary Gland

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

The Analysis of Kisspeptin Neuronal Exosomes and their Effects in the Periphery at the Level of the Bone

Circadian Dysregulation is Associated with Alterations in Tumor Suppressor Activity in Murine Mammary Tissue

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