Index Catalog // ScholarsArchive@OSU

Machine learning approach to improve drug discovery in natural product extracts

Creator:: Heussner, Robert T.
Abstract:: Current natural product (NP) research is limited by its reliance on bioassay-guided fractionation to identify bioactive compounds in mixtures. Computational approaches may improve NP research by correlating mass spectra (MS) and nuclear magnetic resonance spectra (NMR) of bioactive mixtures to their bioactivity patterns. In this study, I use artificial neural...
Resource Type:: Honors College Thesis
Full Text:: . 11. Zhao, F.; Watanabe, Y.; Nozawa, H.; Daikonnya, A.; Kondo, K.; Kitanaka, S. Prenylflavonoids and

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Creator:: Salih, M. Quamar
Abstract:: Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
Resource Type:: Dissertation
Full Text:: !committee,!Prof.!Paul!Blakemore,!Prof.!Paul!Cheong,!Prof.!Kerry!McPhaill! and!Prof.!Steve!Giovanini! for

Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

Creator:: Li, Xin
Abstract:: This dissertation is separated into two parts according to the two major distinct research projects. In Part I, the full account of synthetic studies toward C10-functionalized lycopodium alkaloids is described. In Part II, the detailed discussion on the exploration of the Pummerer cyclization methodology and its application to the total...
Resource Type:: Dissertation
Full Text:: . Paul Blakemore, Prof. Sandra Loesgen, Prof. Paul Ha-Yeon Cheong, Prof. Xiulei Ji and Prof. Liney

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Creator:: Vellucci, Jessica K.
Abstract:: Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...
Resource Type:: Dissertation
Full Text:: communesin F, see: (a) Zhang, D.; Song, H.; Qin, Y. Acc. Chem. Res. 2011, 44, 447. (b) Tanimoto, H

The development of aminal radicals for the synthesis of nitrogen-rich natural products

Creator:: Schiedler, David A.
Abstract:: Organic compounds which contain one or more nitrogen atoms are especially important as they are disproportionately represented among biologically active molecules. As a result, significant effort has been focused on the development of methods for the synthesis of nitrogenous molecules. We identified the aminal as an under-explored functional group. Despite...
Resource Type:: Dissertation
Full Text:: . 2008, 10, 3105–3108. 16 Ikeda, H.; Matsuo, K.; Matsui, Y.; Matsuoka, M.; Mizuno, K. Bull. Chem. Jpn

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation
Full Text:: members, Professor Paul R. Blakemore, Professor Paul Ha-Yeon Cheong, Professor Mas Subramanian, and

Exploratory Studies Within the Exotic Lyonsite Structure

Creator:: Tang, Joseph N.
Abstract:: Structure-property relationships have always underpinned the field of solid state chemistry; dependable structural descriptions are integral to understanding and controlling the physical properties of inorganic compounds old and new. While a handful of crystal structures are celebrated for their versatility, flexibility, and functionality, the existence of more exotic structures is...
Resource Type:: Dissertation
Full Text:: uphold that standard in my future scientific endeavors. I would like to thank Drs. Michael Lerner, Paul

Prediction and Measurement of Polycyclic Aromatic Hydrocarbons (PAHs) Transformation Products in the Environment.

Creator:: Titaley, Ivan A.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a group of environmental contaminants consisting of fused benzene rings. Parent-PAHs, methylated-PAHs (MPAHs), and PAHs with molecular weight of 302 a.m.u (MW302-PAHs) are considered as unsubstituted-PAHs. These unsubstituted-PAHs undergo transformation reactions resulting in the formation of PAH-transformation products (PAH-TPs), or substituted-PAHs, including nitrated-, oxygenated-, and...
Resource Type:: Dissertation
Full Text:: sincerely grateful for the members of my committee, Dr. Jennifer Field, Dr. Paul Ha-Yeon Cheong, Dr. Neal

Formation of hybrid supramolecular assemblies using biological molecules and transition metals

Creator:: Smith, Rachelle M. S.
Abstract:: Naturally occurring assemblies, such as DNA and proteins, utilize intermolecular forces (i.e H-bonding and van der Waals) to assemble. Utilizing these electrostatic interactions has only just started in the past five decades to be a tool used in synthetic chemistry in what is known as supramolecular chemistry. Supramolecular chemistry has...
Resource Type:: Dissertation
Full Text:: Naturally occurring assemblies, such as DNA and proteins, utilize intermolecular forces (i.e H-bonding and

Organic/Inorganic Hybrid Materials of Uranyl Peroxide Clusters and Uranium Minerals

Creator:: Neal, Harrison A.
Abstract:: Frontier research of non-aqueous actinide clusters is discussed. Since the inception of the uranyl peroxide clusters over the last decade, they have only been synthesized and characterized as solid crystals and in aqueous solution. This thesis provides thorough characterization of aqueous uranyl clusters and the first demonstration of uranyl cluster...
Resource Type:: Dissertation

ScholarsArchive@OSU

Machine learning approach to improve drug discovery in natural product extracts

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

The development of aminal radicals for the synthesis of nitrogen-rich natural products

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Exploratory Studies Within the Exotic Lyonsite Structure

Prediction and Measurement of Polycyclic Aromatic Hydrocarbons (PAHs) Transformation Products in the Environment.

Formation of hybrid supramolecular assemblies using biological molecules and transition metals

Organic/Inorganic Hybrid Materials of Uranyl Peroxide Clusters and Uranium Minerals

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