Ceratonova shasta is an obligate endoparasite of salmonid fish that is endemic to the Pacific Northwest of North America. The parasite has a complicated lifecycle with two distinct spore stages and two obligate hosts, a salmonid and a freshwater annelid. Myxospores released from infected salmonid hosts, infect Manayunkia occidentalis (freshwater...
Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
The use of ethionamide has been increasing in drug regiments due to greater incidence of multidrug resistance tuberculosis around the world. Ethionamide is metabolized into antimicrobial relevant compounds by different flavin-containing monooxygenase (FMO) enzymes including FMO1, FMO2, and FMO3. FMOs are found in various locations in the body including the...
Defining the inelastic behavior of nail joints is essential
in the development of a rational design procedure of wood-stud walls.
Prediction equations were developed for the inelastic behavior
of joints commonly found in wood-stud walls. The equations relate
three elastic moduli that define the average inelastic joint stiffness
to the...
Reported here is an investigation to determine the in vitro and in vivo metabolism
of xanthohumol (XN). XN is the major prenylated flavonoid of the female
inflorescences (cones) of the hop plant (Humulus lupulus). It is also a constituent of
beer, the major dietary source of prenylated flavonoids. Recent studies...
Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
The assessment of optimum nitrogen (N) fertilizer need for winter wheat (Triticum
aestivum L.) is important for economic and environmental sustainability. A comprehensive understanding of fertilizer N requirement depends on estimation of the quantity of N needed by the crop versus that supplied by soil.
The objectives of this study...
In a series of greenhouse experiments, isolates representing serotypically
distinct subpopulations of Rhizobium leguminosarum bv. trifolii recovered from root
nodules of field-grown subclover Trifolium subterraneum cv. "Nangeela"), were
evaluated for their symbiotic effectiveness potential, their effect on regrowth
potential of subclover, and for their competitive abilities to form nodules. Isolates...