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  • Computational Approaches for Understanding Combinatorial Gene Regulation

    Creator:
    Ansariola, Mitra
    Abstract:
    Gene regulation is a complex mechanism that controls the spatial and temporal expression of genes in a living cell. My dissertation studies focus on two problems. First, tissue-specific gene expression prediction from DNA sequence and chromatin state, and second, the accurate discovery of small over-represented regulatory circuits in gene regulatory...
    Resource Type:
    Dissertation
    Full Text:
    computational biology community in studying these fundamental scientific questions. 9 Chapter 2: Chromatin

  • Computational methods for protein-protein interface prediction

    Creator:
    Tribelhorn, Benjamin
    Abstract:
    Protein-protein interactions underlie all biological processes and are a field of study that has wide implications throughout many other fields including medicine, genetics, biology, and ecology. Proteins are the building blocks and primary actors of life. They work together to accomplish virtually every task within a cell, including, metabolism, signal...
    Resource Type:
    Dissertation
    Full Text:
    degree of Doctor of Philosophy in Computer Science presented on August 14, 2013. Title: Computational

  • Algorithms for massive biological datasets

    Creator:
    Bryant, Douglas W. (Douglas Wesley)
    Abstract:
    Within the past several years the technology of high-throughput sequencing has transformed the study of biology by offering unprecedented access to life's fundamental building block, DNA. With this transformation's potential a host of brand-new challenges have emerged, many of which lend themselves to being solved through computational methods. From de...
    Resource Type:
    Dissertation
    Full Text:
    techniques. We examine these issues through the lens of computational biology. ©Copyright by Douglas W