Marine algae have been recognized as a rich resource of new
and unusual organic molecules with diverse biological properties.
The current need to develop new antifungal, anticancer, antibiotic
and antiviral drugs has led to an intense research effort into the
discovery, isolation and structure determination of potential
medicinal agents from...
Marine organisms produce a variety of secondary metabolites for defense, communication, and reproduction. While these uses are essential for the organisms' survival, marine natural products have demonstrated their value to human society as well. Asian countries used algae for centuries to treat or prevent illnesses as wide-ranging as cough, gout,...
I have participated in a drug discovery program designed to screen marine algae for
inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances,
and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts
of marine plants and animals were surveyed for biomedical potential. Assays designed to
screen extracts...
The sea offers a wide variety of potentially useful resources. Marine algae have been a rich source of structurally unique natural products showing diverse biological properties. The current need to develop new antifungal, antibiotic, anticancer and antiviral drugs has prompted intense research efforts into the discovery, isolation and structure determination...
This thesis is an account of my investigation on the natural products deriving from various marine algae and has resulted in the discovery of thirteen novel bioactive metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D...
This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...