A mutational analysis was conducted to investigate the functions of the tobacco etch potyvirus VPgproteinase
(NIa) protein in vivo. The NIa N-terminal domain contains the VPg attachment site, whereas the
C-terminal domain contains a picornavirus 3C-like proteinase. Cleavage at an internal site separating the two
domains occurs in a subset...
The purpose of this study was to document the initial change in vegetative canopy cover
following winter seismic exploration on the North Slope of Alaska. The study conducted herein
focuses solely on the impact to wet sedge meadow vegetation.
The overarching goal of this study is to contribute some level...
Background
Feline injection-site sarcoma (FISS) is a rare and aggressive tumor associated with vaccines, drug injections, and skin trauma in cats. The understanding of FISS remains limited, posing challenges in its diagnosis, treatment, and prevention. In this study, we analyzed the differential expression of miRNAs and their target genes in...
Rapid increasing of renewable energies and the knowledge about their environmental effects are very limited. As a result, the renewable energies (e.g. solar or wind energies) will play a vital role in the future because it is well accepted by environmental friendly industries. This dissertation presents the modeling, data analysis...
This thesis uses both feminist and new historic theories to argue that the women's romance novels The Last September (1929) by Elizabeth Bowen and The Country Girl's Trilogy (1960, 1962, 1964) by Edna O'Brien are tragic bildungsroman that subvert and challenge the Irish patriarchal marriage expectations of their respective time...
Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
The enzymes of dNTP synthesis in T4 infection associate to form a multienzyme complex, the T4 dNTP synthetase complex, facilitating the flow of metabolites en route to dNTPs, and their subsequent flow into DNA. Study of protein-protein interactions helps one to understand how the enzymes in the complex are organized...
Ireland's Catholic Church played an important role in the turn-of-the-century nationalism that shaped James Joyce's identity and writing; yet it also played an important part in preventing that nationalism from achieving its goals of autonomy and cultural independence. For Joyce, this was particularly evident in the dialects and
thought structures...