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Filtering by: Committee Member Cui, Zhengrong

Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

Creator:

Zhang, Lingjuan

Abstract:

COUP-TFI, an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily, plays important roles in homeostasis and the CNS development, including differentiation, patterning, axonal projection, cell migration, cortical arealization and the temporal specification of neural stem cells. A number of COUP-interacting proteins have been described previously, and the majority of...

Resource Type:

Dissertation
Effect of pharmaceuticals and natural products on multidrug resistance mediatedtransport in Caco-2 and MDCKII-MDR1 drug transport models

Creator:

Fan, Ying

Abstract:

This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...

Resource Type:

Dissertation

Full Text:

, Dr. Zhengrong Cui, Dr. Virginia M. Lessa, and Dr. Bruce E. Coblentz for their support and academic