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  • Total synthesis of (-)-7-epicylindrospermopsin

    Creator:
    Hansen, Joshua D.
    Abstract:
    The first asymmetric synthesis of (-)-7-epicylindrospermopsin via intramolecular nitrone cycloaddition is described. The synthesis utilized a convergent approach to prepare the cycloaddition precursor 176, which was assembled by condensation of hydroxylamine 175 with aldehyde 145. Hydroxylamine 175 was synthesized from ethylene glycol (166) in seven steps. Aldehyde 145 was completed...
    Resource Type:
    Dissertation
    Full Text:
    has been described, the toxicity varies from one toxin to another, being particularly sensitive to

  • Studies toward the total synthesis of azaspiracid-1

    Creator:
    Kuiper, Damien L.
    Abstract:
    Azaspiracid has generated an enormous amount of scientific interest in the fourteen years since its initial discovery. The structure contains a 6,5,6 bis-spiroketal, a [3.3.1] bicyclic ketal and a 6,5-spiroaminal linkage as key moieties. With 9 rings, 20 stereocenters and three alkenes, the azaspiracid immediately attracted the interest of the...
    Resource Type:
    Dissertation
    Full Text:
    dinophysistoxins prompted investigation into the identity of the causative toxin. In 1998, a toxin with a 0.2 mg

  • Synthetic studies toward the total synthesis of azaspiracid-1

    Creator:
    Su, Dong
    Abstract:
    Azaspiracid-1, a novel marine toxin that contains 9 rings and 20 stereogenic centers, has drawn considerable attention from synthetic groups worldwide due to its structural complexity, which includes a unique trioxabisspiroketal fused to a tetrahydrofuran ring (ABCD rings), a piperidine-tetrahydrofuran spiroaminal system fused to a 2,9-dioxabicyclo[3.3.1]nonane system (FGHI rings), a...
    Resource Type:
    Masters Thesis

  • Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

    Creator:
    Robarge, Lonnie A.
    Resource Type:
    Dissertation
    Full Text:
    synthesis of the marine toxin polycavernoside A. Polycavernoside A was determined to be the causative agent

  • Advances in Freshwater Cyanobacterial Genomics

    Creator:
    Brown, Nathaniel M.
    Abstract:
    Limnology is undergoing a transition to high-throughput -omic analysis of freshwater bacterial communities. An important first step in making the transition is to characterize several genomes that can be used as references to guide metagenome assembly and analysis. Here I characterize four new freshwater cyanobacterial genomes, a pair of lake...
    Resource Type:
    Dissertation
    Full Text:
    produce anatoxin-a (and related toxin variants) is assessed • Two metagenomes of the cyanobacterial