Bitterness is a common flavor attribute of aged cheese, but excessive levels are a flaw leading to consumer rejection. Bitterness in cheese has been primarily associated with milk casein-derived peptides of medium size (500–3,000 Da) and relative hydrophobicity. Herein, we demonstrate a novel approach for the identification of bitter peptides...
Whey protein’s potential for bioactivity is well documented, but there is disagreement on the extent to which it may modulate the immune system towards decreased inflammation. Decreased inflammation is generally perceived as a beneficial bioactivity in foods as excessive chronic inflammation is linked to morbidity and mortality.
This thesis first...
Kappa-casein glycomacropeptide (CMP), a 64-amino-acid peptide, is released from kappa-casein after rennet treatment and is one of the major peptides in whey protein isolate (WPI). CMP has anti-inflammatory and antibacterial activities. CMP has two major amino acid sequences with different modifications including glycosylation, phosphorylation and oxidation. However, no previous work...
Glycomacropeptide (GMP) is a bioactive peptide found in the dairy product whey, along with whey protein isolate (WPI). Past studies have shown that digested GMP retains bioactivity in rodent guts. This study tested whether GMP or GMP-derived peptides or whey protein or whey protein-derived peptides inhibit pro-inflammatory cytokines. THP-1 cells...
Whey protein isolate (WPI) and glycomacropeptide (GMP) have shown potential immunomodulatory properties. In this study, we investigated their effects on pro-inflammatory cytokine secretion using both in vitro and in vivo models. In LPS-stimulated THP-1-derived macrophages, digested WPI and GMP reduced cytokine expression, while whole GMP increased secretion. The in human...
Premature birth interrupts the typical development of the human fetus, leaving the infant born with underdeveloped gastrointestinal and immune systems. Preterm infants have reduced stomach acidity, reduced digestive protease activity, more permeable intestinal membranes, impaired innate and adaptive immune response, and poor microbiome development. Due to these factors, preterm infants...
While breast milk is considered the best nourishment for newborns, they have a lowered ability to digest the fat rich liquid due to decreased lipase secretion for the first few months after birth. To offset this, breast milk itself contains Bile Salt-Stimulated Lipase (BSSL) which significantly heightens fat digestion ability....
Introduction: In the US, irritable bowel syndrome (IBS) affects 1 in 10 people. IBS is a chronic functional gastrointestinal disorder that consists of many gastrointestinal symptoms such as abdominal pain, changes in bowel movement, differences in the appearance of stool, diarrhea, constipation, increased gas, and mucus in stool. IBS causes...
Lactose intolerance is a common food intolerance that occurs because of a post-weaning deficiency of lactase, an enzyme that cleaves the glyosidic bond of lactose. About 75% of the world's population is lactose intolerant. Common symptoms of lactose intolerance are abdominal pain, bloating and diarrhea. ~25% of the world’s population...
Many geophysical phenomena exhibit complicated dynamics that, due to a variety of factors, diverge quickly from physical models. The arrival of new observations allows researchers to combine the model estimate with measurements in a statistical process called data assimilation to produce a revised estimate of the phenomenon. This assimilation of...