Index Catalog // ScholarsArchive@OSU

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

Creator:: Depner, Christopher Michael
Abstract:: Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
Resource Type:: Dissertation
Full Text:: . © Copyright by Christopher Michael Depner July 18, 2013 All Rights Reserved Long-chain (n-3

Potential for Dietary ω-3 Fatty Acids to Prevent Nonalcoholic Fatty Liver Disease and Reduce the Risk of Primary Liver Cancer

Creator:: Jump, Donald B., Depner, Christopher M., Tripathy, Sasmita, and Lytle, Kelli A.
Abstract:: Nonalcoholic fatty liver disease (NAFLD) has increased in parallel with central obesity and its prevalence is anticipated to increase as the obesity epidemic remains unabated. NAFLD is now the most common cause of chronic liver disease in developed countries and is defined as excessive lipid accumulation in the liver, i.e.,...
Resource Type:: Article
Full Text:: , Christopher M. Depner, Sasmita Tripathy and Kelli A. Lytle 6 7 Nutrition Program 8 School of Biological

Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr−/− mice

Creator:: Jump, Donald B., Depner, Christopher M., Tripathy, Sasmita, and Lytle, Kelli A.
Abstract:: The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased in parallel with central obesity and is now the most common chronic liver disease in developed countries. NAFLD is defined as excessive accumulation of lipid in the liver, i.e., hepatosteatosis. The severity of NAFLD ranges from simple fatty liver (steatosis)...
Resource Type:: Article
Full Text:: . Donald B. Jump, Christopher M. Depner, Sasmita Tripathy, Kelli A. Lytle Nutrition Program School of

LytleDocosahexaenoicAcidAttenuatesWesternDiet-InducedHepaticFibrosis.pdf

Creator:: Lytle, Kelli A., Depner, Christopher M., Wong, Carmen P., and Jump, Donald B.
Abstract:: DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
Full Text:: cells . —Lytle, K. A., C. M. Depner, C. P. Wong, and D. B. Jump. Docosahexaenoic acid attenuates

JumpDonaldPublicHealthHumanSciencesOmega-3FattyAcid.pdf

Creator:: Jump, Donald B., Depner, Christopher M., and Tripathy, Sasmita
Abstract:: Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C₂₀₋₂₂ ω3 polyunsaturated fatty acids (PUFA)], blood levels of C₂₀₋₂₂ ω3 PUFA and mortality associated with cardiovascular disease [CVD]. C₂₀₋₂₂ ω3 PUFA have pleiotropic effects on...
Full Text:: Supplementation and Cardiovascular Disease. Donald B. Jump, Christopher M. Depner, Sasmita Tripathy

LytleDocosahexaenoicAcidAttenuatesWesternDiet-InducedHepaticFibrosisSupplementalMaterial.pdf

Creator:: Lytle, Kelli A., Depner, Christopher M., Wong, Carmen P., and Jump, Donald B.
Abstract:: DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
Full Text:: , IL-6DBP, LAP, LIP, NF-IL6, NF-M, Nfil6 Mm.277792 NM_007743 Col1a2 Collagen, type I, alpha 2 AA960264

JumpDonaldPublicHealthHumanSciencesOmega-3FattyAcid(Figures1-4).pptx

Creator:: Jump, Donald B., Depner, Christopher M., and Tripathy, Sasmita
Abstract:: Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C₂₀₋₂₂ ω3 polyunsaturated fatty acids (PUFA)], blood levels of C₂₀₋₂₂ ω3 PUFA and mortality associated with cardiovascular disease [CVD]. C₂₀₋₂₂ ω3 PUFA have pleiotropic effects on...

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

Creator:: Lytle, Kelli A., Depner, Christopher M., Wong, Carmen P., and Jump, Donald B.
Abstract:: DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
Resource Type:: Article

Omega-3 Fatty Acid Supplementation and Cardiovascular Disease

Creator:: Jump, Donald B., Depner, Christopher M., and Tripathy, Sasmita
Abstract:: Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C₂₀₋₂₂ ω3 polyunsaturated fatty acids (PUFA)], blood levels of C₂₀₋₂₂ ω3 PUFA and mortality associated with cardiovascular disease [CVD]. C₂₀₋₂₂ ω3 PUFA have pleiotropic effects on...
Resource Type:: Article

DepnerChristopherNutritionMetabolomicAnalysisOmega-3.pdf

Creator:: Depner, Christopher M., Traber, Maret G., Bobe, Gerd, Kensicki, Elizabeth, Bohren, Kurt M., Milne, Ginger, and Jump, Donald B.
Abstract:: Background: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease and a risk factor for cirrhosis, hepatocellular carcinoma and liver failure. Previously, we reported that dietary docosahexaenoic acid (DHA, 22:6,n-3) was more effective than eicosapentaenoic acid (EPA, 20:5,n-3) at reversing western diet (WD) induced NASH in LDLR-/-...
Full Text:: Christopher M. Depner1,3, Maret G. Traber1,3, Gerd Bobe2,3, Elizabeth Kensicki4, Kurt M. Bohren5, Ginger

ScholarsArchive@OSU

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

Potential for Dietary ω-3 Fatty Acids to Prevent Nonalcoholic Fatty Liver Disease and Reduce the Risk of Primary Liver Cancer

Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr−/− mice

LytleDocosahexaenoicAcidAttenuatesWesternDiet-InducedHepaticFibrosis.pdf

JumpDonaldPublicHealthHumanSciencesOmega-3FattyAcid.pdf

LytleDocosahexaenoicAcidAttenuatesWesternDiet-InducedHepaticFibrosisSupplementalMaterial.pdf

JumpDonaldPublicHealthHumanSciencesOmega-3FattyAcid(Figures1-4).pptx

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

Omega-3 Fatty Acid Supplementation and Cardiovascular Disease

DepnerChristopherNutritionMetabolomicAnalysisOmega-3.pdf

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